Temperature dependence of circular DNA topological states
文献类型：期刊论文
| 作者 | Chen, Hu; Liu, Yanhui; Zhou, Zhen; Hu, Lin; Ou-Yang, Zhong-Can ; Yan, Jie; Chen, H , Natl Univ Singapore, Dept Phys, 2 Sci Dr 3, Singapore 117542, Singapore
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| 刊名 | PHYSICAL REVIEW E
 |
| 出版日期 | 2009 |
| 卷号 | 79期号:4页码:- |
| 关键词 | Double Helix Entropic Elasticity Free-energy Cyclization Fluctuations Simulations Kinking Length Twist |
| ISSN号 | 1539-3755 |
| 英文摘要 | Circular double-stranded DNA has different topological states which are defined by their linking numbers. Equilibrium distribution of linking numbers can be obtained by closing a linear DNA into a circle by ligase. Using Monte Carlo simulation, we predict the temperature dependence of the linking number distribution of small circular DNAs. Our predictions are based on flexible defect excitations that resulted from local melting or unstacking of DNA base pairs. We found that the reduced bending rigidity alone can lead to measurable changes of the variance of linking number distribution of short circular DNAs. If the defect is accompanied by local unwinding, the effect becomes much more prominent. The predictions can be easily investigated in experiments, providing a new method to study the micromechanics of sharply bent DNAs and the thermal stability of specific DNA sequences. Furthermore, the predictions are directly applicable to the studies of binding of DNA-distorting proteins that can locally reduce DNA rigidity, form DNA kinks, or introduce local unwinding. |
| 学科主题 | Physics |
| URL标识 | 查看原文 |
| WOS记录号 | WOS:000265941300120 |
| 公开日期 | 2012-08-02 |
| 源URL | [http://ir.itp.ac.cn/handle/311006/5350]  |
| 专题 | 理论物理研究所_理论物理所1978-2010年知识产出 |
| 通讯作者 | Chen, H , Natl Univ Singapore, Dept Phys, 2 Sci Dr 3, Singapore 117542, Singapore |
| 推荐引用方式 GB/T 7714 | Chen, Hu,Liu, Yanhui,Zhou, Zhen,et al. Temperature dependence of circular DNA topological states[J]. PHYSICAL REVIEW E,2009,79(4):-. |
| APA | Chen, Hu.,Liu, Yanhui.,Zhou, Zhen.,Hu, Lin.,Ou-Yang, Zhong-Can.,...&Chen, H , Natl Univ Singapore, Dept Phys, 2 Sci Dr 3, Singapore 117542, Singapore.(2009).Temperature dependence of circular DNA topological states.PHYSICAL REVIEW E,79(4),-. |
| MLA | Chen, Hu,et al."Temperature dependence of circular DNA topological states".PHYSICAL REVIEW E 79.4(2009):-. |
入库方式： OAI收割
来源：理论物理研究所
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