A cross-species alignment tool (CAT)
文献类型：期刊论文
| 作者 | Li, Heng; Guan, Liang; Liu, Tao; Guo, Yiran; Zheng, Wei-Mou ; Wong, Gane Ka-Shu; Wang, Jun; Zheng, WM , Chinese Acad Sci, Beijing Inst Genom, Beijing 101300, Peoples R China
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| 刊名 | BMC BIOINFORMATICS
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| 出版日期 | 2007 |
| 卷号 | 8期号:1页码:- |
| 关键词 | Genomic Dna Annotation Sequences Programs Database Search Blast |
| ISSN号 | 1471-2105 |
| 英文摘要 | Background: The main two sorts of automatic gene annotation frameworks are ab initio and alignment-based, the latter splitting into two sub-groups. The first group is used for intra-species alignments, among which are successful ones with high specificity and speed. The other group contains more sensitive methods which are usually applied in aligning inter-species sequences. Results: Here we present a new algorithm called CAT ( for Cross-species Alignment Tool). It is designed to align mRNA sequences to mammalian-sized genomes. CAT is implemented using C scripts and is freely available on the web at http://xat.sourceforge.net/. Conclusions: Examined from different angles, CAT outperforms other extant alignment tools. Tested against all available mouse-human and zebrafish-human orthologs, we demonstrate that CAT combines the specificity and speed of the best intra-species algorithms, like BLAT and sim4, with the sensitivity of the best inter-species tools, like GeneWise. |
| 学科主题 | Physics |
| URL标识 | 查看原文 |
| WOS记录号 | WOS:000251410100001 |
| 公开日期 | 2012-08-02 |
| 源URL | [http://ir.itp.ac.cn/handle/311006/5659]  |
| 专题 | 理论物理研究所_理论物理所1978-2010年知识产出 |
| 通讯作者 | Zheng, WM , Chinese Acad Sci, Beijing Inst Genom, Beijing 101300, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Heng,Guan, Liang,Liu, Tao,et al. A cross-species alignment tool (CAT)[J]. BMC BIOINFORMATICS,2007,8(1):-. |
| APA | Li, Heng.,Guan, Liang.,Liu, Tao.,Guo, Yiran.,Zheng, Wei-Mou.,...&Zheng, WM , Chinese Acad Sci, Beijing Inst Genom, Beijing 101300, Peoples R China.(2007).A cross-species alignment tool (CAT).BMC BIOINFORMATICS,8(1),-. |
| MLA | Li, Heng,et al."A cross-species alignment tool (CAT)".BMC BIOINFORMATICS 8.1(2007):-. |
入库方式： OAI收割
来源：理论物理研究所
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