Force modulating dynamic disorder: A physical model of catch-slip bond transitions in receptor-ligand forced dissociation experiments
文献类型：期刊论文
| 作者 | Liu, Fei; Ou-Yang, Zhong-Can ; Liu, F , Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China
|
| 刊名 | PHYSICAL REVIEW E
 |
| 出版日期 | 2006 |
| 卷号 | 74期号:5页码:- |
| 关键词 | Cell-adhesion Molecules L-selectin Shear Lifetime Kinetics Flow |
| ISSN号 | 1539-3755 |
| 英文摘要 | Recent experiments found that some adhesive receptor-ligand complexes have counterintuitive catch-slip transition behaviors: the mean lifetimes of these complexes first increase (catch) with initial application of a small external force, and then decrease (slip) when the force is beyond some threshold. In this work we suggest that the forced dissociation of these complexes might be a typical rate process with dynamic disorder. The one-dimensional force modulating Agmon-Hopfield model is used to describe the transitions in the single-bond P-selectin glycoprotein ligand 1-P-selectin forced dissociation experiments, which were respectively performed in the constant force [Marshall , Nature (Landon) 423, 190 (2003)] and the ramping force [Evans , Proc. Natl. Acad. Sci. U.S.A 98, 11281 (2004)] modes. We find that, an external force can not only accelerate the bond dissociation, but also modulate the complex from the lower-energy barrier to the higher one; the catch-slip bond transition can arise from a particular energy barrier shape. The agreement between our calculation and the experimental data is satisfactory. |
| 学科主题 | Physics |
| URL标识 | 查看原文 |
| WOS记录号 | WOS:000242408700074 |
| 公开日期 | 2012-08-02 |
| 源URL | [http://ir.itp.ac.cn/handle/311006/5867]  |
| 专题 | 理论物理研究所_理论物理所1978-2010年知识产出 |
| 通讯作者 | Liu, F , Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Fei,Ou-Yang, Zhong-Can,Liu, F , Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China. Force modulating dynamic disorder: A physical model of catch-slip bond transitions in receptor-ligand forced dissociation experiments[J]. PHYSICAL REVIEW E,2006,74(5):-. |
| APA | Liu, Fei,Ou-Yang, Zhong-Can,&Liu, F , Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China.(2006).Force modulating dynamic disorder: A physical model of catch-slip bond transitions in receptor-ligand forced dissociation experiments.PHYSICAL REVIEW E,74(5),-. |
| MLA | Liu, Fei,et al."Force modulating dynamic disorder: A physical model of catch-slip bond transitions in receptor-ligand forced dissociation experiments".PHYSICAL REVIEW E 74.5(2006):-. |
入库方式： OAI收割
来源：理论物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。