Single molecule Michaelis-Menten equation beyond quasistatic disorder
文献类型：期刊论文
| 作者 | Xue, Xiaochuan; Liu, Fei; Ou-Yang, Zhong-can ; Xue, X , Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China
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| 刊名 | PHYSICAL REVIEW E
 |
| 出版日期 | 2006 |
| 卷号 | 74期号:3页码:- |
| 关键词 | Electron-transfer Reactions Dynamics Kinetics Enzyme |
| ISSN号 | 1539-3755 |
| 英文摘要 | The classic Michaelis-Menten equation describes the catalytic activities for ensembles of enzyme molecules very well. But recent single-molecule experiments showed that the waiting time distribution and other properties of single enzyme molecules were not consistent with the prediction based on the ensemble viewpoint. They have contributed to the slow conformational changes of a single enzyme in the catalytic processes. In this work, we study the general dynamics of single enzymes in the presence of dynamic disorder. We find that, within the time separation regimes, i.e., the slow reaction and nondiffusion limits, the Michaelis-Menten equation holds exactly. In particular, by employing the decoupling approximation we demonstrate analytically that the classic Michaelis-Menten equation is still an excellent approximation in the presence of general dynamic disorder. |
| 学科主题 | Physics |
| URL标识 | 查看原文 |
| WOS记录号 | WOS:000240870100009 |
| 公开日期 | 2012-08-02 |
| 源URL | [http://ir.itp.ac.cn/handle/311006/5916]  |
| 专题 | 理论物理研究所_理论物理所1978-2010年知识产出 |
| 通讯作者 | Xue, X , Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xue, Xiaochuan,Liu, Fei,Ou-Yang, Zhong-can,et al. Single molecule Michaelis-Menten equation beyond quasistatic disorder[J]. PHYSICAL REVIEW E,2006,74(3):-. |
| APA | Xue, Xiaochuan,Liu, Fei,Ou-Yang, Zhong-can,&Xue, X , Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China.(2006).Single molecule Michaelis-Menten equation beyond quasistatic disorder.PHYSICAL REVIEW E,74(3),-. |
| MLA | Xue, Xiaochuan,et al."Single molecule Michaelis-Menten equation beyond quasistatic disorder".PHYSICAL REVIEW E 74.3(2006):-. |
入库方式： OAI收割
来源：理论物理研究所
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