Pulling hairpinned polynucleotide chains: Does base-pair stacking interaction matter?
文献类型：期刊论文
| 作者 | Zhang, Y; Zhou, HJ ; Zhou, HJ , Max Planck Inst Colloids & Interfaces, D-14424 Potsdam, Germany.
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| 刊名 | JOURNAL OF CHEMICAL PHYSICS
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| 出版日期 | 2001 |
| 卷号 | 114期号:19页码:8694-8700 |
| 关键词 | Double-stranded Dna Rna Secondary Structure Supercoiled Dna Single-molecule Entropic Elasticity Mechanics Model Polymerase |
| ISSN号 | 0021-9606 |
| 英文摘要 | Force-induced structural transitions both in relatively random and in designed single-stranded DNA (ssDNA) chains are studied theoretically. At high salt conditions, ssDNA forms compacted hairpin patterns stabilized by base pairing and base-pair stacking interactions, and a threshold external force is needed to pull the hairpinned structure into a random coiled one. The base-pair stacking interaction in the ssDNA chain makes this hairpin-coil conversion a discontinuous (first-order) phase transition process characterized by a force plateau in the force-extension curve, while lowering this potential below some critical level turns this transition into continuous (second-order) type, no matter how strong the base-pairing interaction is. The phase diagram (including hairpin-I, -II, and random coil) is discussed as a function of stacking potential and external force. These results are in quantitative agreement with recent experimental observations of different ssDNA sequences, and they reveal the necessity to consider the base-pair stacking interactions in order to understand the structural formation of RNA, a polymer designed by nature itself. The theoretical method used may be extended to study the long-range interaction along double-stranded DNA caused by the topological constraint of fixed linking number. (C) 2001 American Institute of Physics. |
| 学科主题 | Physics |
| URL标识 | 查看原文 |
| WOS记录号 | WOS:000168440400053 |
| 公开日期 | 2012-08-29 |
| 源URL | [http://ir.itp.ac.cn/handle/311006/12751]  |
| 专题 | 理论物理研究所_理论物理所1978-2010年知识产出 |
| 通讯作者 | Zhou, HJ , Max Planck Inst Colloids & Interfaces, D-14424 Potsdam, Germany. |
| 推荐引用方式 GB/T 7714 | Zhang, Y,Zhou, HJ,Zhou, HJ , Max Planck Inst Colloids & Interfaces, D-14424 Potsdam, Germany.. Pulling hairpinned polynucleotide chains: Does base-pair stacking interaction matter?[J]. JOURNAL OF CHEMICAL PHYSICS,2001,114(19):8694-8700. |
| APA | Zhang, Y,Zhou, HJ,&Zhou, HJ , Max Planck Inst Colloids & Interfaces, D-14424 Potsdam, Germany..(2001).Pulling hairpinned polynucleotide chains: Does base-pair stacking interaction matter?.JOURNAL OF CHEMICAL PHYSICS,114(19),8694-8700. |
| MLA | Zhang, Y,et al."Pulling hairpinned polynucleotide chains: Does base-pair stacking interaction matter?".JOURNAL OF CHEMICAL PHYSICS 114.19(2001):8694-8700. |
入库方式： OAI收割
来源：理论物理研究所
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