Difference between "proteinlike" and "nonproteinlike" heteropolymers
文献类型：期刊论文
| 作者 | Chen, H; Zhou, X; Ou-Yang, ZC ; Chen, H , Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China.
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| 刊名 | PHYSICAL REVIEW E
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| 出版日期 | 2001 |
| 卷号 | 63期号:3页码:- |
| ISSN号 | 1063-651X |
| 关键词 | Simple-model Sequences Enumeration Transition Simulation Stability Dynamics Fold |
| 英文摘要 | Based on a simple two-dimensional (2D) hydrophobic-polar (H-P) lattice model, properties of amino acid chains are studied by enumeration and Monte-Carlo simulation methods. Among them some chains with Large average energy gap ((E-g) over bar) are thought to be "proteinlike" while the others are "nonproteinlike." The large (E-g) over bar between the low excited conformations and the native conformation guarantees not only the thermodynamic stability of protein but also its fast-folding property. The phase transition from molten globule to the native conformation for the "proteinlike" polymer is found to be of first order, while that for the ''nonproteinlike'' polymer is not. Some properties of chains as a function of (E-g) over bar shows that the transition from "nonproteinlike" to "proteinlike" heteropolymers is continuous. The simulation of folding at different temperature indicates that the main reason why some polymers fold slowly to its native conformation is their low folding temperature which makes the effective energy barrier (E-b/T-f) much higher than "proteinlike" chains. |
| 学科主题 | Physics |
| WOS记录号 | WOS:000167623900068 |
| 公开日期 | 2012-08-29 |
| 源URL | [http://ir.itp.ac.cn/handle/311006/12807]  |
| 专题 | 理论物理研究所_理论物理所1978-2010年知识产出 |
| 通讯作者 | Chen, H , Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China. |
| 推荐引用方式 GB/T 7714 | Chen, H,Zhou, X,Ou-Yang, ZC,et al. Difference between "proteinlike" and "nonproteinlike" heteropolymers[J]. PHYSICAL REVIEW E,2001,63(3):-. |
| APA | Chen, H,Zhou, X,Ou-Yang, ZC,&Chen, H , Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China..(2001).Difference between "proteinlike" and "nonproteinlike" heteropolymers.PHYSICAL REVIEW E,63(3),-. |
| MLA | Chen, H,et al."Difference between "proteinlike" and "nonproteinlike" heteropolymers".PHYSICAL REVIEW E 63.3(2001):-. |
入库方式： OAI收割
来源：理论物理研究所
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