Monte Carlo implementation of supercoiled double-stranded DNA
文献类型：期刊论文
| 作者 | Zhang, Y; Zhou, HJ ; Ou-Yang, ZC; Zhang, Y , Acad Sinica, Inst Theoret Phys, POB 2735, Beijing 100080, Peoples R China.
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| 刊名 | BIOPHYSICAL JOURNAL
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| 出版日期 | 2000 |
| 卷号 | 78期号:4页码:1979-1987 |
| 关键词 | Elasticity Molecule Model Stiffness Mechanics Polymers |
| ISSN号 | 0006-3495 |
| 英文摘要 | Metropolis Monte Carlo simulation is used to investigate the elasticity of torsionally stressed double-stranded DNA, in which twist and supercoiling are incorporated as a natural result of base-stacking interaction and backbone bending constrained by hydrogen bonds formed between DNA complementary nucleotide bases. Three evident regimes are found in extension versus torsion and force versus extension plots: a low-force regime in which over- and underwound molecules behave similarly under stretching; an intermediate-force regime in which chirality appears for negatively and positively supercoiled DNA and extension of underwound molecule is insensitive to the supercoiling degree of the polymer; and a large-force regime in which plectonemic DNA is fully converted to extended DNA and supercoiled DNA behaves quite like a torsionless molecule. The striking coincidence between theoretic calculations and recent experimental measurement of torsionally stretched DNA (Strick et al., Science. 271:1835, 1996; Biophys. J. 74:2016, 1998) strongly suggests that the interplay between base-stacking interaction and permanent hydrogen-bond constraint takes an important role in understanding the novel properties of elasticity of supercoiled DNA polymer. |
| 学科主题 | Physics |
| URL标识 | 查看原文 |
| WOS记录号 | WOS:000086349500029 |
| 公开日期 | 2012-08-29 |
| 源URL | [http://ir.itp.ac.cn/handle/311006/12984]  |
| 专题 | 理论物理研究所_理论物理所1978-2010年知识产出 |
| 通讯作者 | Zhang, Y , Acad Sinica, Inst Theoret Phys, POB 2735, Beijing 100080, Peoples R China. |
| 推荐引用方式 GB/T 7714 | Zhang, Y,Zhou, HJ,Ou-Yang, ZC,et al. Monte Carlo implementation of supercoiled double-stranded DNA[J]. BIOPHYSICAL JOURNAL,2000,78(4):1979-1987. |
| APA | Zhang, Y,Zhou, HJ,Ou-Yang, ZC,&Zhang, Y , Acad Sinica, Inst Theoret Phys, POB 2735, Beijing 100080, Peoples R China..(2000).Monte Carlo implementation of supercoiled double-stranded DNA.BIOPHYSICAL JOURNAL,78(4),1979-1987. |
| MLA | Zhang, Y,et al."Monte Carlo implementation of supercoiled double-stranded DNA".BIOPHYSICAL JOURNAL 78.4(2000):1979-1987. |
入库方式： OAI收割
来源：理论物理研究所
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