The elastic theory of a single DNA molecule
文献类型：期刊论文
| 作者 | Ou-Yang, ZC ; Zhou, H; Zhang, Y; Ou-Yang, ZC , Chinese Acad Sci, Inst Theoret Phys, POB 2735, Beijing 100080, Peoples R China.
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| 刊名 | MODERN PHYSICS LETTERS B
 |
| 出版日期 | 2003 |
| 卷号 | 17期号:1页码:1-10 |
| 关键词 | Double-stranded Dna Polynucleotide Chains Stacking Interactions Transitions Polymerase |
| ISSN号 | 0217-9849 |
| 英文摘要 | We review our recent efforts in understanding the elastic properties of double-stranded (ds) and single-stranded (as) DNA macromolecules. A simple geometric model of dsDNA was constructed and solved by path integral methods. The good agreement with experiments on dsDNA's entropic elasticity, cooperative extensibility, and supercoiling property suggested that the short-ranged base-pair stacking interaction is crucial for the stability and the high deformability of dsDNA. For ssDNA at high ionic conditions, base-pairing and base-pair stacking interactions cause the polymer to fold into compact hairpin configurations. The force-induced hairpin-coil transition was studied with the generating function method. In accordance with experiment, this transition was found to be highly cooperative when the average stacking potential is higher than some critical level. At low ionic conditions, the electrostatic repulsive interaction along the ssDNA becomes dominant, and ssDNA can be regarded as model polyelectrolytes. Our MC simulation results suggested an exponential relation between external force and the total extension. This prediction was confirmed experimentally. |
| 学科主题 | Physics |
| URL标识 | 查看原文 |
| 公开日期 | 2012-08-29 |
| 源URL | [http://ir.itp.ac.cn/handle/311006/13374]  |
| 专题 | 理论物理研究所_理论物理所1978-2010年知识产出 |
| 通讯作者 | Ou-Yang, ZC , Chinese Acad Sci, Inst Theoret Phys, POB 2735, Beijing 100080, Peoples R China. |
| 推荐引用方式 GB/T 7714 | Ou-Yang, ZC,Zhou, H,Zhang, Y,et al. The elastic theory of a single DNA molecule[J]. MODERN PHYSICS LETTERS B,2003,17(1):1-10. |
| APA | Ou-Yang, ZC,Zhou, H,Zhang, Y,&Ou-Yang, ZC , Chinese Acad Sci, Inst Theoret Phys, POB 2735, Beijing 100080, Peoples R China..(2003).The elastic theory of a single DNA molecule.MODERN PHYSICS LETTERS B,17(1),1-10. |
| MLA | Ou-Yang, ZC,et al."The elastic theory of a single DNA molecule".MODERN PHYSICS LETTERS B 17.1(2003):1-10. |
入库方式： OAI收割
来源：理论物理研究所
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