Classification of amino acids based on statistical results of known structures and cooperativity of protein folding
文献类型：期刊论文
| 作者 | Chen, H; Zhou, X; Ou-Yang, ZC ; Chen, H , Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China.
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| 刊名 | PHYSICAL REVIEW E
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| 出版日期 | 2002 |
| 卷号 | 65期号:6页码:- |
| 关键词 | Secondary-structure Globular-proteins Model Sequences Conformation Parameters Copolymers Range |
| ISSN号 | 1539-3755 |
| 英文摘要 | It has been found that the 20 kinds of amino acids have different frequencies of occurrence in alpha,beta, and coil structures [P. Y. Chou and G. D. Fasman, Biochemistry 13, 211 (1974)]. Based on more known structures of proteins, frequencies for each amino acid in alpha and beta secondary structures are recalculated. Next step, under the approximation ignoring the chain connectivity of proteins, energy parameters to form alpha and beta secondary structures for each amino acid are obtained. According to the hydrophobicity and energies in alpha and beta secondary structures, 20 kinds of amino acids are classified. The results suggest that dividing amino acids to five or nine groups is desirable. At last, a protein model considering both two-body hydrophobic interaction and one-body energy to form secondary structures, hydrophobic-polar alphabeta model, is introduced. It is shown that the consistency among various energy terms makes the cooperativity of protein folding closer to the experiments. |
| 学科主题 | Physics |
| URL标识 | 查看原文 |
| WOS记录号 | WOS:000176762500070 |
| 公开日期 | 2012-08-29 |
| 源URL | [http://ir.itp.ac.cn/handle/311006/13512]  |
| 专题 | 理论物理研究所_理论物理所1978-2010年知识产出 |
| 通讯作者 | Chen, H , Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China. |
| 推荐引用方式 GB/T 7714 | Chen, H,Zhou, X,Ou-Yang, ZC,et al. Classification of amino acids based on statistical results of known structures and cooperativity of protein folding[J]. PHYSICAL REVIEW E,2002,65(6):-. |
| APA | Chen, H,Zhou, X,Ou-Yang, ZC,&Chen, H , Tsing Hua Univ, Ctr Adv Study, Beijing 100084, Peoples R China..(2002).Classification of amino acids based on statistical results of known structures and cooperativity of protein folding.PHYSICAL REVIEW E,65(6),-. |
| MLA | Chen, H,et al."Classification of amino acids based on statistical results of known structures and cooperativity of protein folding".PHYSICAL REVIEW E 65.6(2002):-. |
入库方式： OAI收割
来源：理论物理研究所
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