Geometric and statistical properties of the mean-field hydrophobic-polar model, the large-small model, and real protein sequences
文献类型：期刊论文
| 作者 | Shih, CT; Su, ZY; Gwan, JF; Hao, BL; Hsieh, CH; Lo, JL; Lee, HC; Shih, CT , Natl Ctr High Performance Comp, Hsinchu, Taiwan. |
| 刊名 | PHYSICAL REVIEW E
 |
| 出版日期 | 2002 |
| 卷号 | 65期号:4页码:- |
| ISSN号 | 1539-3755 |
| 关键词 | Globular-proteins Aqueous-solution Folding Funnels Amino-acids Designability Transition Stability Polymers Peptide Design |
| 英文摘要 | Lattice models, for their coarse-grained nature, are best suited for the study of the "designability problem," the phenomenon in which most of the about 16 000 proteins of known structure have their native conformations concentrated in a relatively small number of about 500 topological classes of conformations. Here it is shown that on a lattice the most highly designable simulated protein structures are those that have the largest number of surface-core switchbacks. A combination of physical, mathematical, and biological reasons that causes the phenomenon is given. By comparing the most foldable model peptides with protein sequences in the Protein Data Bank, it is shown that whereas different models may yield similar designabilities, predicted foldable peptides will simulate natural proteins only when the model incorporates the correct physics and biology, in this case if the main folding force arises from the differing hydrophobicity of the residues, but does not originate, say, from the steric hindrance effect caused by the differing sizes of the residues. |
| 学科主题 | Physics |
| URL标识 | 查看原文 |
| WOS记录号 | WOS:000175146400097 |
| 公开日期 | 2012-08-29 |
| 源URL | [http://ir.itp.ac.cn/handle/311006/13562]  |
| 专题 | 理论物理研究所_理论物理所1978-2010年知识产出 |
| 通讯作者 | Shih, CT , Natl Ctr High Performance Comp, Hsinchu, Taiwan. |
| 推荐引用方式 GB/T 7714 | Shih, CT,Su, ZY,Gwan, JF,et al. Geometric and statistical properties of the mean-field hydrophobic-polar model, the large-small model, and real protein sequences[J]. PHYSICAL REVIEW E,2002,65(4):-. |
| APA | Shih, CT.,Su, ZY.,Gwan, JF.,Hao, BL.,Hsieh, CH.,...&Shih, CT , Natl Ctr High Performance Comp, Hsinchu, Taiwan..(2002).Geometric and statistical properties of the mean-field hydrophobic-polar model, the large-small model, and real protein sequences.PHYSICAL REVIEW E,65(4),-. |
| MLA | Shih, CT,et al."Geometric and statistical properties of the mean-field hydrophobic-polar model, the large-small model, and real protein sequences".PHYSICAL REVIEW E 65.4(2002):-. |
入库方式： OAI收割
来源：理论物理研究所
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