Limitations of compositional approach to identifying horizontally transferred genes
文献类型：期刊论文
| 作者 | Wang, B; Wang, B , Acad Sinica, Inst Theoret Phys, POB 2735, Beijing 100080, Peoples R China. |
| 刊名 | JOURNAL OF MOLECULAR EVOLUTION
 |
| 出版日期 | 2001 |
| 卷号 | 53期号:3页码:244-250 |
| 关键词 | Escherichia-coli Genome Bacterial Hyperthermophiles Common Ancestry Archaeal Exchange Sequences Tree Life Divergence Evolution |
| ISSN号 | 0022-2844 |
| 英文摘要 | Genes with atypical G+C content and pattern of codon usage in a certain genome are possibly of exotic origin, and this idea has been applied to identify horizontal events. In this way, it was postulated that a total of 755 genes in the E. coli genome are relics of horizontal events after the divergence of E. coli from the Salmonella lineage 100 million years ago (Lawrence and Ochman. 1998). In this paper we propose a new way to study sequence composition more thoroughly. We found that although the 755 genes differ in composition from other genes in the E. coli genome. the difference is minor. If we accepted that these genes are horizontally transferred. then (1) it would be more likely that they were transferred from genomes evolutionarily closely related to E. coli: but (2) the dating method used by Lawrence and Ochman (1997, 1998) largely underestimated the average age of introduced sequences in the E. coli genome, in particular, most of the 755 genes should be introduced into E. coli before, instead of after, the divergence of E. coli from the Salmonella lineage. Our study reveals that atypical G+C content and pattern of codon usage are not reliable indicators of horizontal gene transfer events. |
| 学科主题 | Physics |
| URL标识 | 查看原文 |
| WOS记录号 | WOS:000170659000009 |
| 公开日期 | 2012-08-29 |
| 源URL | [http://ir.itp.ac.cn/handle/311006/13673]  |
| 专题 | 理论物理研究所_理论物理所1978-2010年知识产出 |
| 通讯作者 | Wang, B , Acad Sinica, Inst Theoret Phys, POB 2735, Beijing 100080, Peoples R China. |
| 推荐引用方式 GB/T 7714 | Wang, B,Wang, B , Acad Sinica, Inst Theoret Phys, POB 2735, Beijing 100080, Peoples R China.. Limitations of compositional approach to identifying horizontally transferred genes[J]. JOURNAL OF MOLECULAR EVOLUTION,2001,53(3):244-250. |
| APA | Wang, B,&Wang, B , Acad Sinica, Inst Theoret Phys, POB 2735, Beijing 100080, Peoples R China..(2001).Limitations of compositional approach to identifying horizontally transferred genes.JOURNAL OF MOLECULAR EVOLUTION,53(3),244-250. |
| MLA | Wang, B,et al."Limitations of compositional approach to identifying horizontally transferred genes".JOURNAL OF MOLECULAR EVOLUTION 53.3(2001):244-250. |
入库方式： OAI收割
来源：理论物理研究所
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