Predicting the function of eukaryotic scaffold/matrix attachment regions via DNA mechanics
文献类型：期刊论文
| 作者 | Li, M , Chinese Acad Sci, Inst Theoret Phys, Beijing 100080, Peoples R China.; Li, M ; Ou-Yang, ZC
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| 刊名 | JOURNAL OF PHYSICS-CONDENSED MATTER
 |
| 出版日期 | 2005 |
| 卷号 | 17期号:31页码:S2853-S2860 |
| 关键词 | Domains Gene |
| ISSN号 | 0953-8984 |
| 英文摘要 | Eukaryotic chromatin undergoes a few steps of compaction to form a chromosome. Among the several levels of chromatin assembly, successive chromatin loops (5-100 kb) demarcated by the nuclear matrix are of primary importance since they behave as topologically independent domains for coordinate regulation of harboured genes. The bases of the loops are called SMARs (scaffold/matrix attachment regions). On one hand, this chromosome structure imposes stress on the DNA molecule since the double-stranded DNA is actually unwound and bent by histones and other proteins. On the other hand, the stressed DNA itself affects chromatin assembly inversely, e.g., the unwinding stress may promote SMAR binding to the matrix. The interplay between chromosome structure and unwinding stress contributes significantly to eukaryotic gene regulation. In this paper, we investigate two issues: how torsional stress may promote SMAR anchorage to the matrix; and how the formation of chromatin loops may affect basic biochemical processes. We employ the Benham model for these purposes. Our analysis gives theoretical evidence that at least some SMARs are unwound under torsional stress and at the same time could serve as topological barriers for retaining the torsional stress on the chromatin loop which may be necessary for gene transcription. |
| 学科主题 | Physics |
| URL标识 | 查看原文 |
| WOS记录号 | WOS:000231935000012 |
| 公开日期 | 2012-08-30 |
| 源URL | [http://ir.itp.ac.cn/handle/311006/13763]  |
| 专题 | 理论物理研究所_理论物理所1978-2010年知识产出 |
| 通讯作者 | Li, M , Chinese Acad Sci, Inst Theoret Phys, Beijing 100080, Peoples R China. |
| 推荐引用方式 GB/T 7714 | Li, M , Chinese Acad Sci, Inst Theoret Phys, Beijing 100080, Peoples R China.,Li, M,Ou-Yang, ZC. Predicting the function of eukaryotic scaffold/matrix attachment regions via DNA mechanics[J]. JOURNAL OF PHYSICS-CONDENSED MATTER,2005,17(31):S2853-S2860. |
| APA | Li, M , Chinese Acad Sci, Inst Theoret Phys, Beijing 100080, Peoples R China.,Li, M,&Ou-Yang, ZC.(2005).Predicting the function of eukaryotic scaffold/matrix attachment regions via DNA mechanics.JOURNAL OF PHYSICS-CONDENSED MATTER,17(31),S2853-S2860. |
| MLA | Li, M , Chinese Acad Sci, Inst Theoret Phys, Beijing 100080, Peoples R China.,et al."Predicting the function of eukaryotic scaffold/matrix attachment regions via DNA mechanics".JOURNAL OF PHYSICS-CONDENSED MATTER 17.31(2005):S2853-S2860. |
入库方式： OAI收割
来源：理论物理研究所
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