Advances in the mechanism of mechanochemical coupling of kinesin
文献类型：期刊论文
| 作者 | Li, M ; Ouyang, ZC; Shu, YG; Shu, YG (reprint author), Univ Chinese Acad Sci, Sch Phys Sci, Beijing 100049, Peoples R China.; Shu, YG (reprint author), Chinese Acad Sci, Inst Theoret Phys, Beijing 100190, Peoples R China.
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| 刊名 | ACTA PHYSICA SINICA
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| 出版日期 | 2016 |
| 卷号 | 65期号:18页码:188702 |
| 关键词 | Kinesin Single Molecule Technology Mechanochemical Coupling |
| DOI | http://dx.doi.org/10.7498/aps.65.188702 |
| 英文摘要 | Kinesin is one of the most important linear motors for intracellular transport. It has two main features. One is its persistence: at least one head is attached to the microtubule during stepping, so that it can move a long distance before detaching. Another feature is the tight mechanochemical coupling: it consumes one adenosine-triphosphate for each step. Therefore, there should be a mechanism responsible for the coordination of the two heads to achieve the high persistence and tight coupling. The underlying mechanism is the mechanochemical coupling, which is the basic issue for all chemical-driven molecular motors. Owing to the developments of single-molecule experiments and molecular dynamics simulations, a breakthrough in the coupling mechanism has been made in recent decades. In this article, we review the progress of the relevant researches from the perspective of kinematics, energetics, coordination of two heads and force generating mechanism. We also present a personal perspective on the future studies of kinesin. |
| 学科主题 | Physics |
| 语种 | 中文 |
| 源URL | [http://ir.itp.ac.cn/handle/311006/21529]  |
| 专题 | 理论物理研究所_理论物理所1978-2010年知识产出 |
| 通讯作者 | Shu, YG (reprint author), Univ Chinese Acad Sci, Sch Phys Sci, Beijing 100049, Peoples R China.; Shu, YG (reprint author), Chinese Acad Sci, Inst Theoret Phys, Beijing 100190, Peoples R China. |
| 推荐引用方式 GB/T 7714 | Li, M,Ouyang, ZC,Shu, YG,et al. Advances in the mechanism of mechanochemical coupling of kinesin[J]. ACTA PHYSICA SINICA,2016,65(18):188702. |
| APA | Li, M,Ouyang, ZC,Shu, YG,Shu, YG ,&Shu, YG .(2016).Advances in the mechanism of mechanochemical coupling of kinesin.ACTA PHYSICA SINICA,65(18),188702. |
| MLA | Li, M,et al."Advances in the mechanism of mechanochemical coupling of kinesin".ACTA PHYSICA SINICA 65.18(2016):188702. |
入库方式： OAI收割
来源：理论物理研究所
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