Folate-Conjugated Magnetic Nanoparticles for Tumor Hyperthermia Therapy: In Vitro and In Vivo Studies
文献类型：期刊论文
| 作者 | Zheng, WP; Rong, Z; Gao FP(高福平) ; Gao XY(高学云); Gao J(高靓); Gao, FP; Cai, YY; Zhou, J; Chen, XY; Li, QQ
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| 刊名 | JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
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| 出版日期 | 2016 |
| 卷号 | 16期号:8页码:8352-8359 |
| 关键词 | Hyperthermia Magnetic Nanoparticles Folate KB Cells Tumor |
| DOI | 10.1166/jnn.2016.12622 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Magnetic hyperthermia using ferrite nanoparticles has emerged as a eutherapeutic approach for cancer treatment. In this study, we had constructed folate conjugated poly(ethyleneimine) (PEI) modified magnetic nanoparticles (FA-PEI-MNPs) that generate heat in an alternating magnetic field (AMF). Transmission electron microscope (TEM) showed that FA-PEI-MNPs were nearly spherical in shape. The mean diameter of these nanoparticles determined by DLS was 30.7 +/- 7.7 nm. The cytotoxicity assay showed that FA-PEI-MNPs exhibited no significant cytotoxicity against L929 cells. FA-PEI-MNPs have good hyperthermia effect on KB cells in vitro by magnetic field induced hyperthermia, especially at 45 degrees C and 47 degrees C. In in vivo hyperthermia treatment using FA-PEI-MNPs in a subcutaneous tumor xenograft model of KB cells tumor, the tumor temperature increased to 48 degrees C whereas the body temperature remained at around 37.5 degrees C. Thermotherapy with FA-PEI-MNPs led up to prolongation of survival over magnetic field controls, 66.7% (4/6) of subcutaneous tumors regressed completely. Histological examinations after treatment revealed large necrotic areas close to particle deposits. These results suggest that hyperthermia using FA-PEI-MNPs is an effective and specific therapy for tumor. This therapy may provide an alternative way to treat recurrent cancer refractory to other modalities. |
| WOS关键词 | IRON-OXIDE NANOPARTICLES ; FOCUSED ULTRASOUND ABLATION ; TARGETED DRUG-DELIVERY ; ISSUE-ON REVIEWS ; BREAST-CANCER ; FOLIC-ACID ; BIOMEDICAL APPLICATIONS ; CATIONIC LIPOSOMES ; PROSTATE-CANCER ; NANOMATERIALS |
| 语种 | 英语 |
| WOS记录号 | WOS:000387083900083 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/260247]  |
| 专题 | 高能物理研究所_多学科研究中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Zheng, WP,Rong, Z,Gao FP,et al. Folate-Conjugated Magnetic Nanoparticles for Tumor Hyperthermia Therapy: In Vitro and In Vivo Studies[J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2016,16(8):8352-8359. |
| APA | Zheng, WP.,Rong, Z.,高福平.,高学云.,高靓.,...&Tang, JT.(2016).Folate-Conjugated Magnetic Nanoparticles for Tumor Hyperthermia Therapy: In Vitro and In Vivo Studies.JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,16(8),8352-8359. |
| MLA | Zheng, WP,et al."Folate-Conjugated Magnetic Nanoparticles for Tumor Hyperthermia Therapy: In Vitro and In Vivo Studies".JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 16.8(2016):8352-8359. |
入库方式： OAI收割
来源：高能物理研究所
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