Revealing different aggregational states of a conjugated polymer in solution by a nanopore sensor
文献类型：期刊论文
| 作者 | Guo BY(郭秉元) ; Yao ZY(姚志轶); Liu L(刘蕾); Wu HC(吴海臣); Guo, BY; Yao, ZY; Liu, L; Wu, HC
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| 刊名 | CHEMICAL SCIENCE
 |
| 出版日期 | 2016 |
| 卷号 | 7期号:8页码:5287-5293 |
| DOI | 10.1039/c6sc00296j |
| 通讯作者 | 吴海臣 |
| 文献子类 | 期刊论文 |
| 英文摘要 | The functionalities of conjugated polymers are determined not only by local molecular structure, but also by the mesoscale conformational and morphological states of the polymer chains. Simulation studies have successfully established the connections between molecular structure and conformational states of certain conjugated polymers. However, experimental tools that can accurately discriminate between different conformational and morphological states of conjugated polymers are still scarce. Here, we use a nanopore sensor to analyze different aggregational states of a polythiophene derivative by threading the polymer through the pore under applied potentials. When the fluorescence of the polythiophene is quenched by pH tuning or the presence of Dy3+, the UV-vis and fluorescence spectra of the two solutions appear indistinguishable. However, threading the polymer molecules of these two solutions through an alpha-hemolysin nanopore affords entirely different translocation profiles owing to their different aggregational states. We further substantiate the results by conducting aggregational interconversion experiments and TEM measurements. This work has clearly indicated that nanopores are promising tools for the analysis of aggregational changes of conjugated polymers and may open new avenues for the investigation of aggregational states of biomacromolecules in the context of early disease diagnosis and prognosis. |
| WOS关键词 | ALPHA-HEMOLYSIN NANOPORES ; FIELD-EFFECT TRANSISTORS ; HOST-GUEST INTERACTIONS ; CHEMICAL SENSORS ; DNA ; POLYTHIOPHENES ; CHARGE ; MICRORNAS |
| 语种 | 英语 |
| WOS记录号 | WOS:000380893900060 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/260262]  |
| 专题 | 高能物理研究所_多学科研究中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Guo BY,Yao ZY,Liu L,et al. Revealing different aggregational states of a conjugated polymer in solution by a nanopore sensor[J]. CHEMICAL SCIENCE,2016,7(8):5287-5293. |
| APA | 郭秉元.,姚志轶.,刘蕾.,吴海臣.,Guo, BY.,...&Wu, HC.(2016).Revealing different aggregational states of a conjugated polymer in solution by a nanopore sensor.CHEMICAL SCIENCE,7(8),5287-5293. |
| MLA | 郭秉元,et al."Revealing different aggregational states of a conjugated polymer in solution by a nanopore sensor".CHEMICAL SCIENCE 7.8(2016):5287-5293. |
入库方式： OAI收割
来源：高能物理研究所
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