One-pot synthesis of PEGylated plasmonic MoO3-x hollow nanospheres for photoacoustic imaging guided chemo-photothermal combinational therapy of cancer
文献类型：期刊论文
| 作者 | Gu, ZJ; Bo T(薄涛); Zhao, YL; Zheng XP(郑晓鹏); Zhang X(张潇); Yin WY(尹文艳) ; Yu J(余杰); Dong XH(董兴华); Yong Y(雍媛); Bao, T
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| 刊名 | BIOMATERIALS
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| 出版日期 | 2016 |
| 卷号 | 76页码:11-24 |
| 关键词 | Molybdenum oxides One-pot Hollow nanospheres Drug delivery Theranostics |
| DOI | 10.1016/j.biomaterials.2015.10.048 |
| 通讯作者 | 尹文艳 ; 谷战军 ; 赵宇亮 |
| 英文摘要 | Engineering design of plasmonic nanomaterials as on-demand theranostic nanoagents with imaging, drug carrier, and photothermal therapy (FIT) functions have profound impact on treatment of cancer. Here, a facile 'one-pot' template-free hydrothermal route was firstly developed for synthesis of plasmonic oxygen deficiency molybdenum oxide hollow nanospheres functionalized by poly(ethylene glycol) (PEG-MoO3-x HNSs). The as-prepared PEG-MoO3-x HNSs not only have good biocompatibility but also exhibit obvious localized surface plasmon resonance (LSPR) absorption in the near-infrared (NIR) region. Especially, due to its intrinsic mesoporous properties and effective photothermal conversion efficiency upon 808-nm NIR laser irradiation, the PEG-MoO3-x HNSs can be applied as a pH/NIR laser dual-responsive camptothecin (CPT) drug delivery nanoplatform for chemotherapy as well as PTT to cancer cells. A remarkably improved synergistic therapeutic effect to pancreatic (PANC-1) tumor-bearing mice was obtained compared to the result of chemotherapy or PTT alone. Apart from its application for drug delivery, the PEG-MoO3-x HNSs can also be employed as an effective contrast nanoagent for photoacoustic (PAT) imaging because of its high NIR absorption, making it promising as a theranostic nanoagent for PAT imaging-guided chemo-photothermal combinational cancer therapy in the nanomedicine field. (c) 2015 Elsevier Ltd. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000366961100002 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/260305]  |
| 专题 | 高能物理研究所_多学科研究中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Gu, ZJ,Bo T,Zhao, YL,et al. One-pot synthesis of PEGylated plasmonic MoO3-x hollow nanospheres for photoacoustic imaging guided chemo-photothermal combinational therapy of cancer[J]. BIOMATERIALS,2016,76:11-24. |
| APA | Gu, ZJ.,薄涛.,Zhao, YL.,郑晓鹏.,张潇.,...&Yan, L.(2016).One-pot synthesis of PEGylated plasmonic MoO3-x hollow nanospheres for photoacoustic imaging guided chemo-photothermal combinational therapy of cancer.BIOMATERIALS,76,11-24. |
| MLA | Gu, ZJ,et al."One-pot synthesis of PEGylated plasmonic MoO3-x hollow nanospheres for photoacoustic imaging guided chemo-photothermal combinational therapy of cancer".BIOMATERIALS 76(2016):11-24. |
入库方式： OAI收割
来源：高能物理研究所
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