Facet Energy versus Enzyme-like Activities: The Unexpected Protection of Palladium Nanocrystals against Oxidative Damage
文献类型：期刊论文
| 作者 | Ge, CC; Fang, G; Shen, XM; Chong, Y; Wamer, WG; Gao, XF; Chai, ZF; Chen, CY; Yin, JJ; Chen CY(陈春英) |
| 刊名 | ACS NANO
 |
| 出版日期 | 2016 |
| 卷号 | 10期号:11页码:10436-10445 |
| 关键词 | palladium nanocrystals surface facet enzyme-like activity antioxidants computational chemistry oxidative stress |
| DOI | 10.1021/acsnano.6b06297 |
| 通讯作者 | 陈春英 |
| 文献子类 | 期刊论文 |
| 英文摘要 | To develop nanomaterials as artificial enzymes, it is necessary to better understand how their physicochemical properties affect their enzyme-like activities. Although prior research has demonstrated that nanomaterials exhibit tunable enzyme-like activities depending on their size, structure, and composition, few studies have examined the effect of surface facets, which determine surface energy or surface reactivity. Here, we use electron spin-resonance spectroscopy to report that lower surface energy {111}-faceted Pd octahedrons have greater intrinsic antioxidant enzyme like activity than higher surface energy {100}-faceted Pd nanocubes. Our in vitro experiments found that those same Pd octahedrons are more effective than Pd nanocubes at scavenging reactive oxygen species (ROS). Those reductions in ROS preserve the homogeneity of mitochondrial membrane potential and attenuate damage to important biomolecules, thereby allowing a substantially higher number of cells to survive oxidative challenges. Our computations of molecular mechanisms for the antioxidant activities of {111}- and {100}-faceted Pd nanocrystals, as well as their activity order, agree well with experimental observations. These findings can guide the design of antioxidant-mimicking nanomaterials, which could have therapeutic or preventative potential against oxidative stress related diseases. |
| WOS关键词 | METAL-ORGANIC FRAMEWORKS ; PEROXIDASE-LIKE ACTIVITY ; AUGMENTED-WAVE METHOD ; REACTIVE OXYGEN ; CATALYTIC-ACTIVITY ; ARTIFICIAL ENZYMES ; DNA-DAMAGE ; GLUTATHIONE-PEROXIDASE ; OXIDE NANOPARTICLES ; MOLECULAR-OXYGEN |
| 语种 | 英语 |
| WOS记录号 | WOS:000388913100075 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/260356]  |
| 专题 | 中国科学院高能物理研究所 |
| 通讯作者 | Gao, Xingfa |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Ge, CC,Fang, G,Shen, XM,et al. Facet Energy versus Enzyme-like Activities: The Unexpected Protection of Palladium Nanocrystals against Oxidative Damage[J]. ACS NANO,2016,10(11):10436-10445. |
| APA | Ge, CC.,Fang, G.,Shen, XM.,Chong, Y.,Wamer, WG.,...&Chai, Zhifang.(2016).Facet Energy versus Enzyme-like Activities: The Unexpected Protection of Palladium Nanocrystals against Oxidative Damage.ACS NANO,10(11),10436-10445. |
| MLA | Ge, CC,et al."Facet Energy versus Enzyme-like Activities: The Unexpected Protection of Palladium Nanocrystals against Oxidative Damage".ACS NANO 10.11(2016):10436-10445. |
入库方式： OAI收割
来源：高能物理研究所
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