Synthesis, Crystal Structure and Protein Tyrosine Phosphatase Inhibition of a Copper(II) Complex with N-(2-Pyridylmethyl)-L-serine
文献类型：期刊论文
| 作者 | Li, YH; Yuan, CX; Lu, LP; Zhu, ML; Fu, XQ; Xing, S; Gao, ZQ; Gao ZQ(高增强)
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| 刊名 | CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
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| 出版日期 | 2016 |
| 卷号 | 37期号:12页码:2138-2143 |
| 关键词 | Copper(II) complex N-(2-Pyridylmethyl)-L-serine Inhibitor PTP1B TCPTP |
| DOI | 10.7503/cjcu20160563 |
| 其他题名 | N-(2-吡啶甲基)-L-丝氨酸铜配合物的合成、晶体结构及抑制蛋白酪氨酸磷酸酶活性 |
| 通讯作者 | 高增强 |
| 文献子类 | 期刊论文 |
| 英文摘要 | The reaction of the reduced Schiff base HL [N-(2-pyridylmethyl)-L-serine] with CuCl2 center dot 2H(2)O in molar ratio of 1 : 1 in methanol solution afforded a new neutral mononuclear complex [CuLCl(H2O)] (I). The structure was determined by single. crystal X-ray diffraction and further characterized by elemental analysis, FTIR, electrospray ionization mass spectrometry and powder X-ray diffraction. In complex., the Cu(II) ion adopts five. coordinated mode in a square pyramidal configuration which is completed by one oxygen and two nitrogen atoms from the L- anion, one chloride anion and one water molecule. The discrete copper coordination units were extended into a 2D supramolecular network through the intermolecular interactions. The bioactivity of the compound as a potential PTPs(Protein Tyrosine Phosphatases) inhibitory agent in vitro was investigated, displaying potent inhibition against PTP1B(IC50 = 0.32 mu mol/L) and TCPTP(IC50 = 0.45 mu mol/L). |
| WOS关键词 | SCHIFF-BASE ; COORDINATION POLYMERS ; OXOVANADIUM(IV) COMPLEXES ; POTENT INHIBITION ; CU(II) COMPLEXES ; DERIVATIVES ; LIGAND ; PTP1B ; BINDING ; ACIDS |
| 语种 | 中文 |
| WOS记录号 | WOS:000389192700003 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/260357]  |
| 专题 | 中国科学院高能物理研究所 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Li, YH,Yuan, CX,Lu, LP,et al. Synthesis, Crystal Structure and Protein Tyrosine Phosphatase Inhibition of a Copper(II) Complex with N-(2-Pyridylmethyl)-L-serine[J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2016,37(12):2138-2143. |
| APA | Li, YH.,Yuan, CX.,Lu, LP.,Zhu, ML.,Fu, XQ.,...&高增强.(2016).Synthesis, Crystal Structure and Protein Tyrosine Phosphatase Inhibition of a Copper(II) Complex with N-(2-Pyridylmethyl)-L-serine.CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,37(12),2138-2143. |
| MLA | Li, YH,et al."Synthesis, Crystal Structure and Protein Tyrosine Phosphatase Inhibition of a Copper(II) Complex with N-(2-Pyridylmethyl)-L-serine".CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE 37.12(2016):2138-2143. |
入库方式： OAI收割
来源：高能物理研究所
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