热门
Functionalized Nano-MoS2 with Peroxidase Catalytic and Near-Infrared Photothermal Activities for Safe and Synergetic Wound Antibacterial Applications
文献类型：期刊论文
| 作者 | Yin WY(尹文艳) ; Yu J(于杰); Yan L(晏亮); Zheng LR(郑黎荣); Gu ZJ(谷战军); Zhao YL(赵宇亮); Yin, WY; Yu, J; Lv, FT; Yan, L
|
| 刊名 | ACS NANO
 |
| 出版日期 | 2016 |
| 卷号 | 10期号:12页码:11000-11011 |
| 关键词 | MoS2 peroxidase-like activity wound disinfection photothermal therapy |
| DOI | 10.1021/acsnano.6b05810 |
| 通讯作者 | 尹文艳 ; 谷战军 ; 赵宇亮 |
| 英文摘要 | We have developed a biocompatible antibacterial system based on polyethylene glycol functionalized molybdenum disulfide nanoflowers (PEG-MoS2 NFs). The PEG-MoS2 NFs have high near-infrared (NIR) absorption and peroxidase-like activity, which can efficiently catalyze decomposition of low concentration of H2O2 to generate hydroxyl radicals (center dot OH). The conversion of H2O2 into center dot OH can avoid the toxicity of high concentration of H2O2 and the center dot OH has higher antibacterial activity, making resistant bacteria more vulnerable and wounds more easily cured. The PEG-MoS2 NFs combine the catalysis with MR photothermal effect, providing a rapid and effective killing outcome in vitro for Gram-negative ampicillin resistant Escherichia coli (Amp(r) E. coli) and Gram-positive endospore-forming Bacillus subtilis (B. subtilis) as compared to catalytic treatment or photothermal therapy (PTT) alone. Wound healing results indicate that the synergy antibacterial system could be conveniently used for wound disinfection in vivo. Interestingly, glutathione (GSH) oxidation can be accelerated due to the 808 mu irradiation induced hyperthermia at the presence of PEG-MoS2 NFs proved by X-ray near-edge absorption spectra and X-ray spectroscopy. The accelerated GSH oxidation can result in bacterial death more easily. A mechanism based on center dot OH-enhanced PTT is proposed to explain the antibacterial process. |
| 语种 | 英语 |
| WOS记录号 | WOS:000391079700044 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/260372]  |
| 专题 | 高能物理研究所_多学科研究中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Yin WY,Yu J,Yan L,et al. Functionalized Nano-MoS2 with Peroxidase Catalytic and Near-Infrared Photothermal Activities for Safe and Synergetic Wound Antibacterial Applications[J]. ACS NANO,2016,10(12):11000-11011. |
| APA | 尹文艳.,于杰.,晏亮.,郑黎荣.,谷战军.,...&Zhao, YL.(2016).Functionalized Nano-MoS2 with Peroxidase Catalytic and Near-Infrared Photothermal Activities for Safe and Synergetic Wound Antibacterial Applications.ACS NANO,10(12),11000-11011. |
| MLA | 尹文艳,et al."Functionalized Nano-MoS2 with Peroxidase Catalytic and Near-Infrared Photothermal Activities for Safe and Synergetic Wound Antibacterial Applications".ACS NANO 10.12(2016):11000-11011. |
入库方式： OAI收割
来源：高能物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。