Characterization and Preclinical Perspectives of Organic Small Molecule Drug Metabolites in Drug-drug Interactions
文献类型：期刊论文
| 作者 | Gao, LQ; Chen J(陈俊) ; Hu Y(胡毅); Chen, J; Hu, Y; Sun, HY; Ong, YS; Zhang, JX; Chai, ZF; Lee, SS
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| 刊名 | CURRENT ORGANIC CHEMISTRY
 |
| 出版日期 | 2016 |
| 卷号 | 20期号:17页码:1827-1834 |
| 关键词 | Bupropion drug-drug interactions (DDIs) gemfibrozil metabolites pharmacodynamics pharmacokinetics |
| DOI | 10.2174/1385272820666151102212542 |
| 通讯作者 | 胡毅 |
| 文献子类 | 期刊论文 |
| 英文摘要 | The potential of metabolites to contribute to drug-drug interactions (DDIs) has not been well defined so far. However, metabolites of parent drug compounds can contribute to both side effects and DDIs. To address this unmet challenge, we introduce recent advances as well as our perspectives of the metabolites in DDIs in this review. Firstly, we review several typical examples of organic small molecule drug metabolites as major contributors to DDIs in clinic. Since some of the metabolites are so important in the contributions to DDIs, we then further review how to identify active metabolites in vivo and when such metabolites should trigger DDI assessment. Lastly, we review in vivo animal models, especially humanized/chimeric mice, in improving the quality of preclinical DDI assessments. |
| WOS关键词 | MESSENGER-RNA EXPRESSION ; HUMAN CYTOCHROMES P450 ; PREGNANE-X RECEPTOR ; TYROSINEMIA TYPE-I ; HUMANIZED LIVER ; CHIMERIC MICE ; CLINICAL PHARMACOKINETICS ; TRICYCLIC ANTIDEPRESSANTS ; PLASMA-CONCENTRATIONS ; HEPATIC-DYSFUNCTION |
| 语种 | 英语 |
| WOS记录号 | WOS:000380833700008 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/260380]  |
| 专题 | 高能物理研究所_多学科研究中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Gao, LQ,Chen J,Hu Y,et al. Characterization and Preclinical Perspectives of Organic Small Molecule Drug Metabolites in Drug-drug Interactions[J]. CURRENT ORGANIC CHEMISTRY,2016,20(17):1827-1834. |
| APA | Gao, LQ.,陈俊.,胡毅.,Chen, J.,Hu, Y.,...&Lee, SS.(2016).Characterization and Preclinical Perspectives of Organic Small Molecule Drug Metabolites in Drug-drug Interactions.CURRENT ORGANIC CHEMISTRY,20(17),1827-1834. |
| MLA | Gao, LQ,et al."Characterization and Preclinical Perspectives of Organic Small Molecule Drug Metabolites in Drug-drug Interactions".CURRENT ORGANIC CHEMISTRY 20.17(2016):1827-1834. |
入库方式： OAI收割
来源：高能物理研究所
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