Identification of a Novel Parallel beta-Strand Conformation within Molecular Monolayer of Amyloid Peptide
文献类型：期刊论文
| 作者 | Liu, L; Li, Q; Zhang, S; Wang, XF; Hoffmann, SV; Li, JY; Liu, Z; Besenbacher, F; Dong, MD; Wang XF(王晓峰)
|
| 刊名 | ADVANCED SCIENCE
 |
| 出版日期 | 2016 |
| 卷号 | 3期号:6 |
| DOI | 10.1002/advs.201500369 |
| 文献子类 | 期刊论文 |
| 英文摘要 | The differentiation of protein properties and biological functions arises from the variation in the primary and secondary structure. Specifically, in abnormal assemblies of protein, such as amyloid peptide, the secondary structure is closely correlated with the stable ensemble and the cytotoxicity. In this work, the early A beta(33-42) aggregates forming the molecular monolayer at hydrophobic interface are investigated. The molecular monolayer of amyloid peptide A beta(33-42) consisting of novel parallel beta-strand-like structure is further revealed by means of a quantitative nanomechanical spectroscopy technique with force controlled in pico-Newton range, combining with molecular dynamic simulation. The identified parallel beta-strand-like structure of molecular monolayer is distinct from the antiparallel beta-strand structure of A beta(33-42) amyloid fibril. This finding enriches the molecular structures of amyloid peptide aggregation, which could be closely related to the pathogenesis of amyloid disease. |
| WOS关键词 | ALZHEIMERS-DISEASE ; FORCE MICROSCOPY ; FIBRIL FORMATION ; PROTEIN ; OLIGOMERS ; SPECTROSCOPY ; MECHANISM ; BEAMLINES ; TOXICITY ; MODEL |
| 语种 | 英语 |
| WOS记录号 | WOS:000379934800005 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/260390]  |
| 专题 | 高能物理研究所_多学科研究中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Liu, L,Li, Q,Zhang, S,et al. Identification of a Novel Parallel beta-Strand Conformation within Molecular Monolayer of Amyloid Peptide[J]. ADVANCED SCIENCE,2016,3(6). |
| APA | Liu, L.,Li, Q.,Zhang, S.,Wang, XF.,Hoffmann, SV.,...&李敬源.(2016).Identification of a Novel Parallel beta-Strand Conformation within Molecular Monolayer of Amyloid Peptide.ADVANCED SCIENCE,3(6). |
| MLA | Liu, L,et al."Identification of a Novel Parallel beta-Strand Conformation within Molecular Monolayer of Amyloid Peptide".ADVANCED SCIENCE 3.6(2016). |
入库方式： OAI收割
来源：高能物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。