A pyruvate decarboxylase-mediated therapeutic strategy for mimicking yeast metabolism in cancer cells
文献类型：期刊论文
| 作者 | Scott, B; Shen, JL; Nizzero, S; Boom, K; Persano, S; Mi, Y; Liu, XW; Zhao, YL; Blanco, E; Shen, HF |
| 刊名 | PHARMACOLOGICAL RESEARCH
 |
| 出版日期 | 2016 |
| 卷号 | 111页码:413-421 |
| 关键词 | Cancer metabolism Multistage vector Nanotechnology Pyruvate decarboxylase Warburg effect |
| DOI | 10.1016/j.phrs.2016.07.005 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Cancer cells have high rates of glycolysis and lactic acid fermentation in order to fuel accelerated rates of cell division (Warburg effect). Here, we present a strategy for merging cancer and yeast metabolism to remove pyruvate, a key intermediate of cancer cell metabolism, and produce the toxic compound acetaldehyde. This approach was achieved by administering the yeast enzyme pyruvate decarboxylase to triple negative breast cancer cells. To overcome the challenges of protein delivery, a nanoparticle-based system consisting of cationic lipids and porous silicon were employed to obtain efficient intracellular uptake. The results demonstrate that the enzyme therapy decreases cancer cell viability through production of acetaldehyde and reduction of lactic acid fermentation. (C) 2016 Elsevier Ltd. All rights reserved. |
| WOS关键词 | NEGATIVE BREAST-CANCER ; MULTISTAGE VECTOR DELIVERY ; IN-VIVO ; PHOTOTHERMAL THERAPY ; SILICON PARTICLES ; LUNG METASTASIS ; SIRNA ; NANOPARTICLES ; ACETALDEHYDE ; DEGRADATION |
| 语种 | 英语 |
| WOS记录号 | WOS:000384784000040 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/260396]  |
| 专题 | 高能物理研究所_多学科研究中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Scott, B,Shen, JL,Nizzero, S,et al. A pyruvate decarboxylase-mediated therapeutic strategy for mimicking yeast metabolism in cancer cells[J]. PHARMACOLOGICAL RESEARCH,2016,111:413-421. |
| APA | Scott, B.,Shen, JL.,Nizzero, S.,Boom, K.,Persano, S.,...&赵宇亮.(2016).A pyruvate decarboxylase-mediated therapeutic strategy for mimicking yeast metabolism in cancer cells.PHARMACOLOGICAL RESEARCH,111,413-421. |
| MLA | Scott, B,et al."A pyruvate decarboxylase-mediated therapeutic strategy for mimicking yeast metabolism in cancer cells".PHARMACOLOGICAL RESEARCH 111(2016):413-421. |
入库方式： OAI收割
来源：高能物理研究所
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