Hesperetin Liposomes for Cancer Therapy
文献类型：期刊论文
| 作者 | Wolfram, J; Scott, B; Boom, K; Shen, JL; Borsoi, C; Suri, K; Grande, R; Fresta, M; Celia, C; Zhao, YL |
| 刊名 | CURRENT DRUG DELIVERY
 |
| 出版日期 | 2016 |
| 卷号 | 13期号:5页码:711-719 |
| 关键词 | Breast cancer Drug delivery Flavanone Lung cancer MDR-1 Natural products |
| DOI | 10.2174/1567201812666151027142412 |
| 英文摘要 | Hesperetin is a compound from citrus fruit that has previously been found to exert anticancer activity through a variety of mechanisms. However, the application of hesperetin to cancer therapy has been hampered by its hydrophobicity, necessitating the use of toxic solubilizing agents. Here, we have developed the first liposome-based delivery system for hesperetin. Liposomes were fabricated using the thin-layer evaporation technique and physical and pharmacological parameters were measured. The liposomes remained stable for prolonged periods of time in serum and under storage conditions, and displayed anticancer efficacy in both H441 lung cancer cells and MDA-MB-231 breast cancer cells. Furthermore, the anticancer activity was not impaired in cells expressing the multidrug resistance protein 1 (MDR-1). In conclusion, the encapsulation of hesperetin in liposomes does not interfere with therapeutic efficacy and provides a biocompatible alternative to toxic solubilizing agents, thereby enabling future clinical use of this compound for cancer therapy. |
| 语种 | 英语 |
| WOS记录号 | WOS:000384800000008 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/260404]  |
| 专题 | 高能物理研究所_多学科研究中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Wolfram, J,Scott, B,Boom, K,et al. Hesperetin Liposomes for Cancer Therapy[J]. CURRENT DRUG DELIVERY,2016,13(5):711-719. |
| APA | Wolfram, J.,Scott, B.,Boom, K.,Shen, JL.,Borsoi, C.,...&赵宇亮.(2016).Hesperetin Liposomes for Cancer Therapy.CURRENT DRUG DELIVERY,13(5),711-719. |
| MLA | Wolfram, J,et al."Hesperetin Liposomes for Cancer Therapy".CURRENT DRUG DELIVERY 13.5(2016):711-719. |
入库方式： OAI收割
来源：高能物理研究所
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