Metformin is a novel suppressor for transforming growth factor (TGF)-beta 1
文献类型：期刊论文
| 作者 | Xiao, H; Zhang, JS; Xu ZH(徐钟河); Li JY(李敬源) ; Xu, ZH; Feng, YA; Zhang, ML; Liu, JL; Chen, RF; Shen, J
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| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2016 |
| 卷号 | 6 |
| DOI | 10.1038/srep28597 |
| 英文摘要 | Metformin is a widely used first-line antidiabetic drug that has been shown to protect against a variety of specific diseases in addition to diabetes, including cardiovascular disorders, polycystic ovary syndrome, and cancer. However, the precise mechanisms underlying the diverse therapeutic effects of metformin remain elusive. Here, we report that transforming growth factor-beta 1 (TGF-beta 1), which is involved in the pathogenesis of numerous diseases, is a novel target of metformin. Using a surface plasmon resonance-based assay, we identified the direct binding of metformin to TGF-beta 1 and found that metformin inhibits [I-125]-TGF-beta 1 binding to its receptor. Furthermore, based on molecular docking and molecular dynamics simulations, metformin was predicted to interact with TGF-beta 1 at its receptor-binding domain. Single-molecule force spectroscopy revealed that metformin reduces the binding probability but not the binding force of TGF-beta 1 to its type II receptor. Consequently, metformin suppresses type II TGF-beta 1 receptor dimerization upon exposure to TGF-beta 1, which is essential for downstream signal transduction. Thus, our results indicate that metformin is a novel TGF-beta suppressor with therapeutic potential for numerous diseases in which TGF-beta 1 hyperfunction is indicated. |
| 语种 | 英语 |
| WOS记录号 | WOS:000378789000001 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/260407]  |
| 专题 | 中国科学院高能物理研究所 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Xiao, H,Zhang, JS,Xu ZH,et al. Metformin is a novel suppressor for transforming growth factor (TGF)-beta 1[J]. SCIENTIFIC REPORTS,2016,6. |
| APA | Xiao, H.,Zhang, JS.,徐钟河.,李敬源.,Xu, ZH.,...&Zhang, YY.(2016).Metformin is a novel suppressor for transforming growth factor (TGF)-beta 1.SCIENTIFIC REPORTS,6. |
| MLA | Xiao, H,et al."Metformin is a novel suppressor for transforming growth factor (TGF)-beta 1".SCIENTIFIC REPORTS 6(2016). |
入库方式： OAI收割
来源：高能物理研究所
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