Structural analysis of Pseudomonas aeruginosa H3-T6SS immunity proteins
文献类型：期刊论文
| 作者 | Yang, XY; Li, ZQ; She Z(佘准); Geng Z(耿直); Xu JH(徐建华) ; Gao ZQ(高增强); Dong YH(董宇辉); She, Z; Geng, Z; Xu, JH
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| 刊名 | FEBS LETTERS
 |
| 出版日期 | 2016 |
| 卷号 | 590期号:16页码:2787-2796 |
| 关键词 | immunity protein molecular docking Sel1-like repeats super-ring type VI secretion system |
| DOI | 10.1002/1873-3468.12291 |
| 通讯作者 | 董宇辉 |
| 英文摘要 | The Pseudomonas aeruginosa PldB protein is a transkingdom effector secreted by the Type VI Secretion System (T6SS). PA5088, PA5087, and PA5086 are three immunity proteins that can suppress the virulence of PldB. We report the crystal structures of PA5088 and PA5087 at 2.0 and 2.1 angstrom resolution, respectively. PA5088 and PA5087 both consist of several Sel1-like Repeats (SLRs) and form super-ring folds. Our structural analysis of these proteins revealed key differences among PA5088, PA5087, and their homologs. Our docking experiments have shed light on the putative interaction mechanism of their function as phospholipase D inhibitors. |
| 语种 | 英语 |
| WOS记录号 | WOS:000383600300029 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/260413]  |
| 专题 | 中国科学院高能物理研究所 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Yang, XY,Li, ZQ,She Z,et al. Structural analysis of Pseudomonas aeruginosa H3-T6SS immunity proteins[J]. FEBS LETTERS,2016,590(16):2787-2796. |
| APA | Yang, XY.,Li, ZQ.,佘准.,耿直.,徐建华.,...&Dong, YH.(2016).Structural analysis of Pseudomonas aeruginosa H3-T6SS immunity proteins.FEBS LETTERS,590(16),2787-2796. |
| MLA | Yang, XY,et al."Structural analysis of Pseudomonas aeruginosa H3-T6SS immunity proteins".FEBS LETTERS 590.16(2016):2787-2796. |
入库方式： OAI收割
来源：高能物理研究所
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