Multifunctional WS2@Poly(ethylene imine) Nanoplatforms for Imaging Guided Gene-Photothermal Synergistic Therapy of Cancer
文献类型：期刊论文
| 作者 | Zhang, CF; Yong Y(雍媛); Yong, Y; Song, L; Dong, XH; Zhang, X; Liu, XF; Gu, ZJ; Zhao, YL; Hu, ZB |
| 刊名 | ADVANCED HEALTHCARE MATERIALS
 |
| 出版日期 | 2016 |
| 卷号 | 5期号:21页码:2776-2787 |
| 关键词 | gene therapy mild hyperthermia photoaccoustic imaging photothermal therapy synergistic therapy WS2@PEI nanoplatform X-ray computed tomography |
| DOI | 10.1002/adhm.201600633 |
| 通讯作者 | 谷战军 ; 赵宇亮 |
| 英文摘要 | The combination of photothermal therapy (PTT) with gene therapy (GT) to improve PTT efficiency and thus eliminate cancer cells under mild hyperthermia is highly needed. Herein, multifunctional WS2@poly(ethylene imine) (WS2@PEI) nanoplatform has been designed and constructed for gene-photothermal synergistic therapy of tumors at mild condition. After a surface modification of WS2 with a positively charged PEI, the as-prepared WS2@PEI nanoplatform can not only act as an efficient survivin-siRNA carrier for GT but also exhibit remarkable near-infrared (NIR) photothermal effects for PTT. On the one hand, the photothermal effects induced by WS2@PEI upon NIR irradiation can enhance the cellular uptake owing to the increase of the cell membrane permeability, which leads to the remarkable enhancement of silencing efficiency of survivin. On the other hand, the silencing of survivin can increase the apoptosis as well as reduce the heat resistance of cancer cells by downregulating the heat shock protein 70 expressions, which greatly enhance the sensitivity of cancer cells to PTT. As a result, compared to PTT or GT treatment alone, WS2@PEI mediated synergistic GT/PTT therapy remarkably enhances in vitro cancer cell damage and in vivo tumor elimination. |
| 语种 | 英语 |
| WOS记录号 | WOS:000387662700007 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/260417]  |
| 专题 | 中国科学院高能物理研究所 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Zhang, CF,Yong Y,Yong, Y,et al. Multifunctional WS2@Poly(ethylene imine) Nanoplatforms for Imaging Guided Gene-Photothermal Synergistic Therapy of Cancer[J]. ADVANCED HEALTHCARE MATERIALS,2016,5(21):2776-2787. |
| APA | Zhang, CF.,雍媛.,Yong, Y.,Song, L.,Dong, XH.,...&赵宇亮.(2016).Multifunctional WS2@Poly(ethylene imine) Nanoplatforms for Imaging Guided Gene-Photothermal Synergistic Therapy of Cancer.ADVANCED HEALTHCARE MATERIALS,5(21),2776-2787. |
| MLA | Zhang, CF,et al."Multifunctional WS2@Poly(ethylene imine) Nanoplatforms for Imaging Guided Gene-Photothermal Synergistic Therapy of Cancer".ADVANCED HEALTHCARE MATERIALS 5.21(2016):2776-2787. |
入库方式： OAI收割
来源：高能物理研究所
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