Folic acid-conjugated superparamagnetic iron oxide nanoparticles for tumor-targeting MR imaging
文献类型：期刊论文
| 作者 | Wu, XL; Li L(李雷); Li, L; Gao, FM; Jiang, WW; Cai, YY; Tang, JT; Gao, XY; Gao, FP; Gao XY(高学云)
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| 刊名 | DRUG DELIVERY
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| 出版日期 | 2016 |
| 卷号 | 23期号:5页码:1726-1733 |
| 关键词 | Fe3O4 magnetic nanoparticles MR imaging poly(ethyleneimine) tumor targeting |
| DOI | 10.3109/10717544.2015.1006404 |
| 英文摘要 | Superparamagnetic iron oxide nanoparticles (SPIONs) have been the subject of extensive research due to their potential biomedical applications. In the present investigation, superparamagnetic FA-PEI-Fe3O4 were successfully prepared and evaluated as a targeted MRI contrast agent. FTIR characteristics, TGA, VSM, and MR imaging confirmed the composition and magnetic properties of the synthesized nanoparticles. TEM showed that FA-PEI-Fe3O4 were spherical in shape and well dispersed. The nanoparticles were superparamagnetic at room temperature with a saturation magnetization value of 67.1 emu/g. The nanoparticles showed higher uptake efficiency due to receptor-mediated endocytosis. Moreover, specificity of FA-PEI-Fe3O4 to target tumor cells was demonstrated by the increased nanoparticle uptake and significant contrast enhancement of KB cells over MCF7 cells. The competitive inhibition of FA-PEI-Fe3O4 by free FA further confirmed the specific interaction of this conjugate with FA receptors. In vivo MR imaging studies showed a decreased signal intensity and enhanced tumor contrast post-injection of FA-PEI-Fe3O4. These results indicate that FA-PEI-Fe3O4 can be used as a promising tumor-targeting agent as well as a T-2 negative-contrast agent in MR imaging applications. |
| 语种 | 英语 |
| WOS记录号 | WOS:000382949300023 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/260445]  |
| 专题 | 中国科学院高能物理研究所 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Wu, XL,Li L,Li, L,et al. Folic acid-conjugated superparamagnetic iron oxide nanoparticles for tumor-targeting MR imaging[J]. DRUG DELIVERY,2016,23(5):1726-1733. |
| APA | Wu, XL.,李雷.,Li, L.,Gao, FM.,Jiang, WW.,...&高福平.(2016).Folic acid-conjugated superparamagnetic iron oxide nanoparticles for tumor-targeting MR imaging.DRUG DELIVERY,23(5),1726-1733. |
| MLA | Wu, XL,et al."Folic acid-conjugated superparamagnetic iron oxide nanoparticles for tumor-targeting MR imaging".DRUG DELIVERY 23.5(2016):1726-1733. |
入库方式： OAI收割
来源：高能物理研究所
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