Elevated mercury bound to serum proteins in methylmercury poisoned rats after selenium treatment
文献类型：期刊论文
| 作者 | Li, B; Jing, H; Xu, XH; Zhao, JT; Li YF(李玉锋) ; Gao, YX; Li, YF; Shang, LH; Li B(李柏); Gao YX(高愈希)
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| 刊名 | BIOMETALS
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| 出版日期 | 2016 |
| 卷号 | 29期号:5页码:893-903 |
| 关键词 | Methylmercury Selenite Albumin SEC-ICP-MS MALDI-TOF-MS Rats |
| DOI | 10.1007/s10534-016-9961-1 |
| 通讯作者 | 李玉锋 |
| 英文摘要 | Methylmercury is a toxic pollutant and is generated by microbial methylation of elemental or inorganic mercury in the environment. Previous study found decreased hepatic MDA levels and urinary mercury levels in methylmercury poisoned rats after sodium selenite treatment. This study further found increased mercury levels in serum samples from methylmercury poisoned rats after selenium treatment. By using size exclusion chromatography coupled to inductively coupled plasma mass spectrometry, three Hg- binding protein fractions and two Se-binding protein fractions were identified with the molecular weight of approximately 21, 40, and 75 kDa and of 40 and 75 kDa, respectively. Elevated mercury level in the 75 kDa protein fraction was found binding with both Hg and Se, which may explain the decreased urinary Hg excretion in MeHg poisoned rats after Se treatment. MALDI-TOF-MS analysis of the serum found that the 75 kDa protein fractions were albumin binding with both Hg and Se and the 21 kDa fraction was Hg- binding metallothionein. |
| 语种 | 英语 |
| WOS记录号 | WOS:000385252400012 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/260449]  |
| 专题 | 高能物理研究所_多学科研究中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Li, B,Jing, H,Xu, XH,et al. Elevated mercury bound to serum proteins in methylmercury poisoned rats after selenium treatment[J]. BIOMETALS,2016,29(5):893-903. |
| APA | Li, B.,Jing, H.,Xu, XH.,Zhao, JT.,李玉锋.,...&景晖.(2016).Elevated mercury bound to serum proteins in methylmercury poisoned rats after selenium treatment.BIOMETALS,29(5),893-903. |
| MLA | Li, B,et al."Elevated mercury bound to serum proteins in methylmercury poisoned rats after selenium treatment".BIOMETALS 29.5(2016):893-903. |
入库方式： OAI收割
来源：高能物理研究所
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