Elemental Bio-imaging of Biological Samples by Laser Ablation-Inductively Coupled Plasma-Mass Spectrometry
文献类型：期刊论文
| 作者 | Zheng, LN; Wang, HL; Shi, JW; Feng, WY; Li, L; Wang, M; Zhang XY(张新颖) ; Zheng LN(郑令娜); Wang HL(王海龙); Shi JW(史俊稳)
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| 刊名 | CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
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| 出版日期 | 2016 |
| 卷号 | 44期号:11页码:1646-1651 |
| 关键词 | Inductively coupled plasma-mass spectrometry Laser ablation Elemental bio-imaging Single cell analysis Mouse brain sections Gold nanoparticles |
| DOI | 10.1016/S1872-2040(16)60969-6 |
| 其他题名 | 基于激光剥蚀-电感耦合等离子体质谱技术的生物元素成像分析 |
| 通讯作者 | 王萌 |
| 英文摘要 | Trace elements play very important roles in biological organism and are closely related to many diseases. New analytical methods are urgently needed for in situ determination of trace elements in biological tissues or single cells. A method based on laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) was developed here for in situ analysis. Line ablation mode was chosen and the output energy of the laser was optimized at a low fluence of less than 1 J cm(-2). Two kinds of elemental image of both a coronal section from mouse brain and single cells exposed to gold nanoparticles were obtained by the developed method. Due to the unique characteristic, such as good spatial resolution, excellent detection limit, and reasonable running cost, LA-ICP-MS will be applied widely and become a useful tool in biomedical research in the future. |
| 语种 | 中文 |
| WOS记录号 | WOS:000389520000002 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/260490]  |
| 专题 | 高能物理研究所_多学科研究中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Zheng, LN,Wang, HL,Shi, JW,et al. Elemental Bio-imaging of Biological Samples by Laser Ablation-Inductively Coupled Plasma-Mass Spectrometry[J]. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,2016,44(11):1646-1651. |
| APA | Zheng, LN.,Wang, HL.,Shi, JW.,Feng, WY.,Li, L.,...&Zhang, XY.(2016).Elemental Bio-imaging of Biological Samples by Laser Ablation-Inductively Coupled Plasma-Mass Spectrometry.CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,44(11),1646-1651. |
| MLA | Zheng, LN,et al."Elemental Bio-imaging of Biological Samples by Laser Ablation-Inductively Coupled Plasma-Mass Spectrometry".CHINESE JOURNAL OF ANALYTICAL CHEMISTRY 44.11(2016):1646-1651. |
入库方式： OAI收割
来源：高能物理研究所
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