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Synthesis and biological studies of Tc-99m(HYNIC-MFL)(tricine)(TPPTS) as a novel tumor imaging agent

文献类型：期刊论文

;
作者Wang, J.1,2; Yang, W.1,2; Xue, J.1,2; Zhang, Y.1,2; Han, W.1,2; Liu, Y.1,2
刊名JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY ; JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
出版日期2016 ; 2016
卷号310期号:3页码:1209-1213
关键词Tc-99m(HYNIC-MFL)(tricine)(TPPTS) Tc-99m(HYNIC-MFL)(tricine)(TPPTS) Melphalan Label Tumor imaging Melphalan Label Tumor imaging
ISSN号0236-5731
DOI10.1007/s10967-016-4955-6 ; 10.1007/s10967-016-4955-6
通讯作者汪建军 ; Wang, J.(wangjianjun@ihep.ac.cn) ; Liu, Y.(yuliu@ihep.ac.cn) ; 刘宇（多）
文献子类Article
英文摘要This work reports the synthesis, radiolabeling and biological studies of Tc-99m(HYNIC-MFL)(tricine)(TPPTS) in tumor-bearing mice. The novel melphalan derivative was successfully synthesized by conjugation of HYNIC to melphalan. The ligand could be labeled by Tc-99m in high yield to get Tc-99m(HYNIC-MFL)(tricine)(TPPTS), which was very hydrophilic and was stable at room temperature. Biodistribution studies in tumor-bearing mice showed that Tc-99m(HYNIC-MFL)(tricine)(TPPTS) accumulated in the tumor with favorable uptake and retention. The good accumulation in tumor tissue, high tumor/muscle ratios and satisfactory scintigraphic images highlight the potential of Tc-99m(HYNIC-MFL)(tricine)(TPPTS) for tumor imaging.; This work reports the synthesis, radiolabeling and biological studies of Tc-99m(HYNIC-MFL)(tricine)(TPPTS) in tumor-bearing mice. The novel melphalan derivative was successfully synthesized by conjugation of HYNIC to melphalan. The ligand could be labeled by Tc-99m in high yield to get Tc-99m(HYNIC-MFL)(tricine)(TPPTS), which was very hydrophilic and was stable at room temperature. Biodistribution studies in tumor-bearing mice showed that Tc-99m(HYNIC-MFL)(tricine)(TPPTS) accumulated in the tumor with favorable uptake and retention. The good accumulation in tumor tissue, high tumor/muscle ratios and satisfactory scintigraphic images highlight the potential of Tc-99m(HYNIC-MFL)(tricine)(TPPTS) for tumor imaging.
电子版国际标准刊号1588-2780
WOS关键词RADIOPHARMACEUTICALS ; DNA
资助项目National Key Basic Research Program of China[2013CB932703] ; National Natural Science Foundation of China[11575211] ; National Natural Science Foundation of China[21371172] ; National Natural Science Foundation of China[11475198] ; National Natural Science Foundation of China[21401198]
WOS研究方向Chemistry ; Nuclear Science & Technology
语种英语
WOS记录号WOS:000388629900030 ; WOS:000388629900030
出版者SPRINGER
资助机构National Key Basic Research Program of China ; National Natural Science Foundation of China
源URL[http://ir.ihep.ac.cn/handle/311005/260536]  
专题高能物理研究所_多学科研究中心
高能物理研究所_核技术应用研究中心
通讯作者Wang, J.; Liu, Y.
作者单位1.Chinese Acad Sci, Inst High Energy Phys, Key Lab Nucl Radiat & Nucl Energy Technol, Beijing 100049, Peoples R China
2.Beijing Engn Res Ctr Radiog Tech & Equipment, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Wang, J.,Yang, W.,Xue, J.,et al. Synthesis and biological studies of Tc-99m(HYNIC-MFL)(tricine)(TPPTS) as a novel tumor imaging agent, Synthesis and biological studies of Tc-99m(HYNIC-MFL)(tricine)(TPPTS) as a novel tumor imaging agent[J]. JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY,2016, 2016,310, 310(3):1209-1213, 1209-1213.
APA Wang, J.,Yang, W.,Xue, J.,Zhang, Y.,Han, W.,&Liu, Y..(2016).Synthesis and biological studies of Tc-99m(HYNIC-MFL)(tricine)(TPPTS) as a novel tumor imaging agent.JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY,310(3),1209-1213.
MLA Wang, J.,et al."Synthesis and biological studies of Tc-99m(HYNIC-MFL)(tricine)(TPPTS) as a novel tumor imaging agent".JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY 310.3(2016):1209-1213.

入库方式： OAI收割

来源：高能物理研究所

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