Near-Infrared Light-Triggered Switchable Nanoparticles for Targeted Chemo/Photothermal Cancer Therapy
文献类型：期刊论文
| 作者 | Gao, JM; Gao, H; Bi Y(毕颖); Chen J(陈俊) ; Wen KK(温凯凯); Chai ZF(柴之芳); Hu Y(胡毅); Bi, Y; Chen, J; Peng, LR
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| 刊名 | ACS APPLIED MATERIALS & INTERFACES
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| 出版日期 | 2016 |
| 卷号 | 8期号:24页码:15103 |
| 关键词 | stimuli-responsive nanoparticles size-switchable chemo/photothermal therapy vascular permeability |
| DOI | 10.1021/acsami.6b03905 |
| 通讯作者 | 胡毅 |
| 英文摘要 | Accumulation of nanoparticles in solid tumors depends on their extravasation, but their efficacy is often compromised by intrinsic physiological heterogeneity in tumors. The conventional solutions to circumvent this problem are size control of nanoparticles or increasing the vascular permeability. The aim of this study is to investigate the combination effect of size variation of stimuli-responsive nanoparticles and improved vascular permeability triggered by near-infrared (NIR) light irradiation. Doxorubicin (DOX), a clinically proven drug for bladder cancer, was encapsulated in the nanocomposites with high loading content up to 45%. We show that NIR light-responsive size-switchable nanocarriers could considerably enhance the tumor-targeting of DOX in bladder tumor-bearing mice. Moreover, a combination of NIR-induced hyperthermia and DOXmediated chemotherapy resulted in remarkable inhibition of tumor growth in mice. Histological results suggest that the change in morphology of tumor microvasculature may account for enhanced extravasation and accumulation of the nanodrugs upon NIR irradiation. Together, these data suggest that external stimuli-responsive drug delivery system offers a safe and effective means of targeted chemo/photothermal therapy. |
| 语种 | 英语 |
| WOS记录号 | WOS:000378584800025 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/261062]  |
| 专题 | 高能物理研究所_院士 高能物理研究所_多学科研究中心 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Gao, JM,Gao, H,Bi Y,et al. Near-Infrared Light-Triggered Switchable Nanoparticles for Targeted Chemo/Photothermal Cancer Therapy[J]. ACS APPLIED MATERIALS & INTERFACES,2016,8(24):15103. |
| APA | Gao, JM.,Gao, H.,毕颖.,陈俊.,温凯凯.,...&Hu, Y.(2016).Near-Infrared Light-Triggered Switchable Nanoparticles for Targeted Chemo/Photothermal Cancer Therapy.ACS APPLIED MATERIALS & INTERFACES,8(24),15103. |
| MLA | Gao, JM,et al."Near-Infrared Light-Triggered Switchable Nanoparticles for Targeted Chemo/Photothermal Cancer Therapy".ACS APPLIED MATERIALS & INTERFACES 8.24(2016):15103. |
入库方式： OAI收割
来源：高能物理研究所
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