Blood oxygen level-dependent signals via fMRI in the mood-regulating circuit using two animal models of depression are reversed by chronic escitalopram treatment
文献类型：期刊论文
| 作者 | Geng, LY; Teng, GJ; Nie, BB; Dan BC(单保慈); Nie BB(聂彬彬); Zhang, ZJ; Reynold, GP; Dong, L; Shan, BC; Hui, JJ |
| 刊名 | BEHAVIOURAL BRAIN RESEARCH
 |
| 出版日期 | 2016 |
| 卷号 | 311页码:210 |
| 关键词 | Depression Rat Magnetic resonance imaging Blood oxygen level-dependent Escitalopram |
| DOI | 10.1016/j.bbr.2016.05.044 |
| 英文摘要 | Background: People exposed to stressful experience are at increased risk of the development of depression. A number of functional imaging studies have found disturbances in the mood-regulating circuit of the stress-exposed depressed patients, although few animal imaging studies have been undertaken addressing the brain functional changes of depression. Methods: Two rat models of depression: maternal separation (MS) and chronic unpredictable mild stress (CUMS), imitating early life stress and adult stress respectively, were administered with escitalopram. The differences in functional brain changes were determined by blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI). Results: Increased BOLD activation was observed in some brain regions of MS and CUMS animals, such as the bilateral hypothalamus, limbic system, hippocampus and frontal lobe, which were parts of mood regulating circuit. Furthermore, the MS- and CUMS-induced increases in BOLD activation were partially attenuated by chronic escitalopram treatment. Conclusions: These results suggested hyperactivation of mood-regulating circuit at baseline in the depressed animals exposed to stressful experience, and escitalopram can at least partially reverse these effects. (C) 2016 Elsevier B.V. All rights reserved. |
| WOS记录号 | WOS:000380418200023 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/260518]  |
| 专题 | 中国科学院高能物理研究所 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Geng, LY,Teng, GJ,Nie, BB,et al. Blood oxygen level-dependent signals via fMRI in the mood-regulating circuit using two animal models of depression are reversed by chronic escitalopram treatment[J]. BEHAVIOURAL BRAIN RESEARCH,2016,311:210. |
| APA | Geng, LY.,Teng, GJ.,Nie, BB.,单保慈.,聂彬彬.,...&Li, XL.(2016).Blood oxygen level-dependent signals via fMRI in the mood-regulating circuit using two animal models of depression are reversed by chronic escitalopram treatment.BEHAVIOURAL BRAIN RESEARCH,311,210. |
| MLA | Geng, LY,et al."Blood oxygen level-dependent signals via fMRI in the mood-regulating circuit using two animal models of depression are reversed by chronic escitalopram treatment".BEHAVIOURAL BRAIN RESEARCH 311(2016):210. |
入库方式： OAI收割
来源：高能物理研究所
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