Early Non-invasive Detection of Acute 1,2-Dichloroethane-induced Toxic Encephalopathy in Rats
文献类型：期刊论文
| 作者 | Cao, YZ; Leuze, C; Nie, BB; Shan, BC; Zhou, WB; Xiao, B; Nie BB(聂彬彬); Cipriano, P; Dan BC(单保慈); Zhou, XL |
| 刊名 | IN VIVO
 |
| 出版日期 | 2016 |
| 卷号 | 30期号:6页码:787 |
| 关键词 | 1,2-Dichloroethane exposure diffusion magnetic resonance imaging brain edema toxic encephalopathy |
| DOI | 10.21873/invivo.10995 |
| 英文摘要 | Aim: To assess the acute effect of 1,2-dichloroethane (1,2-DCE) on rat brain using diffusion magnetic resonance imaging (dMRI). Materials and Methods: We performed dMRI on 30 male Sprague-Dawley rats, microstructural alterations were investigated by calculating the mean fractional anisotropy (FA) and apparent diffusion coefficient (ADC) changes in eight selected brain regions of interest. For the whole brain, clusters of 20+ voxels that differed significantly in FA and ADC between groups were marked. Hematoxylin-eosin staining was performed to confirm pathological changes. Results: Brain images showed lesions with brain edema in the white matter in both hemispheres in all groups exposed to 1,2-DCE. Diffusivity values were significantly different after 1,2-DCE inhalation (p<0.05). Conclusion: Primarily cytotoxic edema occurred in acute 1,2-DCE-induced brain edema in rats. dMRI could be used for the early non-invasive detection of acute 1,2-DCE-induced toxic encephalopathy. |
| WOS记录号 | WOS:000392926200009 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/260527]  |
| 专题 | 中国科学院高能物理研究所 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Cao, YZ,Leuze, C,Nie, BB,et al. Early Non-invasive Detection of Acute 1,2-Dichloroethane-induced Toxic Encephalopathy in Rats[J]. IN VIVO,2016,30(6):787. |
| APA | Cao, YZ.,Leuze, C.,Nie, BB.,Shan, BC.,Zhou, WB.,...&Zhou, XL.(2016).Early Non-invasive Detection of Acute 1,2-Dichloroethane-induced Toxic Encephalopathy in Rats.IN VIVO,30(6),787. |
| MLA | Cao, YZ,et al."Early Non-invasive Detection of Acute 1,2-Dichloroethane-induced Toxic Encephalopathy in Rats".IN VIVO 30.6(2016):787. |
入库方式： OAI收割
来源：高能物理研究所
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