Crossover between Anti- and Pro-oxidant Activities of Graphene Quantum Dots in the Absence or Presence of Light
文献类型：期刊论文
| 作者 | Chai ZF(柴之芳) ; Chong, Y; Ge, CC; Fang, G; Tian, X; Ma, XC; Wen, T; Wamer, WG; Chen, CY; Chai, ZF
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| 刊名 | ACS NANO
 |
| 出版日期 | 2016 |
| 卷号 | 10期号:9页码:8690 |
| 关键词 | graphene quantum dots free radicals anti-oxidants phototoxicity lipid peroxidation |
| DOI | 10.1021/acsnano.6b04061 |
| 英文摘要 | Graphene quantum dots (GQDs), zero dimensional carbon materials displaying excellent luminescence properties, show great promise for medical applications such as imaging, drug delivery, biosensors, and novel therapeutics. A deeper understanding of how the properties of GQDs interact with biological systems is essential for these applications. Our work demonstrates that GQDs can efficiently scavenge a number of free radicals and thereby protect cells against oxidative damage. However, upon exposure to blue light, GQDs exhibit significant phototoxicity through increasing intracellular reactive oxygen species (ROS) levels and reducing cell viability, attributable to the generation of free radicals under light excitation. We confirm that light-induced formation of ROS originates from the electron-hole pair and, more importantly, reveal that singlet oxygen is generated by photoexcited GQDs via both energy-transfer and electron-transfer pathways. Moreover, upon light excitation, GQDs accelerate the oxidation of non-enzymic anti-oxidants and promote lipid peroxidation, contributing to the phototoxicity of GQDs. Our results reveal that GQDs can display both anti- and pro-oxidant activities, depending upon light exposure, which will be useful in guiding the safe application and development of potential anticancer/antibacterial applications for GQDs. |
| 语种 | 英语 |
| WOS记录号 | WOS:000384399300062 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/261069]  |
| 专题 | 高能物理研究所_院士 |
| 作者单位 | 中国科学院高能物理研究所 |
| 推荐引用方式 GB/T 7714 | Chai ZF,Chong, Y,Ge, CC,et al. Crossover between Anti- and Pro-oxidant Activities of Graphene Quantum Dots in the Absence or Presence of Light[J]. ACS NANO,2016,10(9):8690. |
| APA | 柴之芳.,Chong, Y.,Ge, CC.,Fang, G.,Tian, X.,...&陈春英.(2016).Crossover between Anti- and Pro-oxidant Activities of Graphene Quantum Dots in the Absence or Presence of Light.ACS NANO,10(9),8690. |
| MLA | 柴之芳,et al."Crossover between Anti- and Pro-oxidant Activities of Graphene Quantum Dots in the Absence or Presence of Light".ACS NANO 10.9(2016):8690. |
入库方式： OAI收割
来源：高能物理研究所
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