preparation and characterization of uniform nanosized cephradine by combination of reactive precipitation and liquid anti-solvent precipitation under high gravity environment
文献类型：期刊论文
| 作者 | Zhong J ; Shen ZG ; Yang Ye ; Chen JF |
| 刊名 | International Journal of Pharmaceutics
 |
| 出版日期 | 2005 |
| 卷号 | 301期号:40180页码:286-293 |
| 关键词 | nanosized pharmaceuticals cephradine reactive precipitation liquid anti-solvent precipitation dissolving time PARTICLE-SIZE REDUCTION DISSOLUTION NANOPARTICLES ENHANCEMENT ANTISOLVENT IMPROVEMENT TECHNOLOGY DRUGS |
| 通讯作者 | Chen, JF (通讯作者), Beijing Univ Chem Technol, Minist Educ High Grav Engn & Technol, Res Ctr,Minist Educ, Key Lab Nanomat, 15 Bei San Huan Dong Rd,POB 35, Beijing 100029, Peoples R China |
| 收录类别 | SCI |
| 公开日期 | 2010-08-23 |
| 附注 | In this work, a novel direct method, which was combined with reactive precipitation and liquid anti-solvent precipitation under high gravity environment, had been developed to prepare nanosized cephradine with narrow particle size distribution. Compared with commercial crude cephradine, the prepared cephradine showed a significant decrease in particle size, a significant increase in the specific surface area and shorter dissolving time when used for injection. The characteristic particle size was between 200-400 nm. The specific surface area increased from 2.95 to 10.87 m(2)/g after micronization. When the amount Of L-arginin decreased from 0.25 to 0.18 g, the mixture of nanosized cephradine and L-arginine could still dissolve in 1 min. The X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FT-IR) analysis indicated that the physical characteristics and molecular states remained unchanged after the recrystallization process. This method had potential application in industrial fields because of its low cost, efficient processing and the ease of scaling-up. (C) 2005 Elsevier B.V. All rights reserved. |
| 源URL | [http://124.16.136.157/handle/311060/3930]  |
| 专题 | 软件研究所_互联网软件技术实验室 _期刊论文 |
| 推荐引用方式 GB/T 7714 | Zhong J,Shen ZG,Yang Ye,et al. preparation and characterization of uniform nanosized cephradine by combination of reactive precipitation and liquid anti-solvent precipitation under high gravity environment[J]. International Journal of Pharmaceutics,2005,301(40180):286-293. |
| APA | Zhong J,Shen ZG,Yang Ye,&Chen JF.(2005).preparation and characterization of uniform nanosized cephradine by combination of reactive precipitation and liquid anti-solvent precipitation under high gravity environment.International Journal of Pharmaceutics,301(40180),286-293. |
| MLA | Zhong J,et al."preparation and characterization of uniform nanosized cephradine by combination of reactive precipitation and liquid anti-solvent precipitation under high gravity environment".International Journal of Pharmaceutics 301.40180(2005):286-293. |
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来源：软件研究所
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