Family-based association tests for different family structures using pooled DNA
文献类型：期刊论文
| 作者 | Zou, GH; Zhao, HY |
| 刊名 | ANNALS OF HUMAN GENETICS
 |
| 出版日期 | 2005-07-01 |
| 卷号 | 69页码:429-442 |
| 关键词 | family-based association study family structure DNA pooling measurement error sample size |
| ISSN号 | 0003-4800 |
| DOI | 10.1046/j.1529-8817.2005.00164.x |
| 英文摘要 | DNA pooling is a cost-effective strategy for genomewise association studies to identify disease genes. In the context of family-based association studies, Risch & Teng (1998) mainly considered fan-lilies of identical structures to detect associations between genetic markers and disease, and suggested possible approaches to incorporating different family types without a thorough study of their properties. However, families collected in real genetic studies often have different structures and, more importantly, the informativeness of each,family structure depends on the disease model which is generally unknown. So there is a need to develop and investigate statistical methods to combine information from diverse family types. In this article, we propose a general strategy to incorporate different family types by assigning each family an "optimal" weight in association tests. In addition, we consider measurement errors in our analysis. When we evaluate our approach under different disease models and measurement errors, we find that our weighting scheme may lead to a substantial reduction in sample size required over the approach suggested by Risch & Teng (1998), and measurement errors may have significant impact on the required sample size when the error rates are not negligible. |
| WOS研究方向 | Genetics & Heredity |
| 语种 | 英语 |
| WOS记录号 | WOS:000230637800008 |
| 出版者 | BLACKWELL PUBLISHING |
| 源URL | [http://ir.amss.ac.cn/handle/2S8OKBNM/1926]  |
| 专题 | 中国科学院数学与系统科学研究院 |
| 通讯作者 | Zhao, HY |
| 作者单位 | 1.Yale Univ, Sch Med, Dept Epidemiol & Publ Hlth, New Haven, CT 06520 USA 2.Chinese Acad Sci, Acad Math & Syst Sci, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zou, GH,Zhao, HY. Family-based association tests for different family structures using pooled DNA[J]. ANNALS OF HUMAN GENETICS,2005,69:429-442. |
| APA | Zou, GH,&Zhao, HY.(2005).Family-based association tests for different family structures using pooled DNA.ANNALS OF HUMAN GENETICS,69,429-442. |
| MLA | Zou, GH,et al."Family-based association tests for different family structures using pooled DNA".ANNALS OF HUMAN GENETICS 69(2005):429-442. |
入库方式： OAI收割
来源：数学与系统科学研究院
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