Association of G72/G30 polymorphisms with early-onset and male schizophrenia
文献类型：期刊论文
| 作者 | Yue, Weihua; Liu, Zhonghua; Kang, Guolian; Yan, Jun; Tang, Fulei; Ruan, Yan; Zhang, Jifeng; Zhang, Dai |
| 刊名 | NEUROREPORT
 |
| 出版日期 | 2006-12-18 |
| 卷号 | 17期号:18页码:1899-1902 |
| 关键词 | age at onset association study G72/G30 polymorphism schizophrenia |
| ISSN号 | 0959-4965 |
| 英文摘要 | To explore the effect of G72/G30 polymorphisms on the clinical manifestations of schizophrenia, especially on the age at onset and sex of patients, we examined three single nucleotide polymorphisms in 216 schizophrenic patients and 321 healthy controls. Significant associations of schizophrenia with the A allele of rs947267 (P = 0.012) and haplotype A-A-G (rs2391191-rs947267-rs778294) (P = 0.008) were found in early-onset schizophrenic patients. So did the same allele (P = 0.034) and haplotype (P = 0.009) as mentioned above in male patients. These findings suggest that the G72/G30 gene may modulate the age at onset and there might be a potential interaction between this locus and sex in the pathogenesis of schizophrenia. |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000243538600013 |
| 出版者 | LIPPINCOTT WILLIAMS & WILKINS |
| 源URL | [http://ir.amss.ac.cn/handle/2S8OKBNM/3254]  |
| 专题 | 中国科学院数学与系统科学研究院 |
| 通讯作者 | Zhang, Dai |
| 作者单位 | 1.Peking Univ, Inst Mental Hlth, Beijing 100083, Peoples R China 2.Chinese Acad Sci, Acad Math & Syst Sci, Beijing, Peoples R China 3.Michigan State Univ, Dept Stat & Probabil, E Lansing, MI 48824 USA |
| 推荐引用方式 GB/T 7714 | Yue, Weihua,Liu, Zhonghua,Kang, Guolian,et al. Association of G72/G30 polymorphisms with early-onset and male schizophrenia[J]. NEUROREPORT,2006,17(18):1899-1902. |
| APA | Yue, Weihua.,Liu, Zhonghua.,Kang, Guolian.,Yan, Jun.,Tang, Fulei.,...&Zhang, Dai.(2006).Association of G72/G30 polymorphisms with early-onset and male schizophrenia.NEUROREPORT,17(18),1899-1902. |
| MLA | Yue, Weihua,et al."Association of G72/G30 polymorphisms with early-onset and male schizophrenia".NEUROREPORT 17.18(2006):1899-1902. |
入库方式： OAI收割
来源：数学与系统科学研究院
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