The study of neighboring nucleotide composition and transition/transversion bias
文献类型：期刊论文
| 作者 | Zhao Hui; Li Qizhai; Li Jun; Zeng Changqing; Hu Songnian; Yu Jun |
| 刊名 | SCIENCE IN CHINA SERIES C-LIFE SCIENCES
 |
| 出版日期 | 2006-08-01 |
| 卷号 | 49期号:4页码:395-402 |
| 关键词 | base substitution SNP transition bias transition transversion |
| ISSN号 | 1006-9305 |
| DOI | 10.1007/s11427-006-2002-5 |
| 英文摘要 | Base substitution is one of the raw fuels that produce genetic variation and drive evolution. Recent studies have shown that the genome components affect mutation patterns to some extent. In order to infer the correlation between the Transition/Transversion ratio (Ts/TV) and the number of immediately adjacent A&T nucleotides, we investigated 3611007 Oryza sativa SNPs (including 45462 coding SNPs, and 242811 intronic SNPs) and 32019 Arabidopsis SNPs. The results show that Ts/Tv is negatively correlated with the number of immediately adjacent A&T in O. sativa and Arabidopsis. We further calculated AT(2) (the number of SNPs whose immediately adjacent nucleoticles are either A or T) and AT(0) (the number of SNPs whose immediately adjacent nucleotides are either C or G) for all 6 types of SNPs. C/G SNP of O. sativa and Arabidopsis has the highest AT(2)/AT(0), which denotes C/G SNP may be influenced by the adjacent A&T nucleotides mostly. For SNPs in O. sativa, the neighboring effect of A&T nucleotides is limited to 2 nucleotides on both sides; for SNPs in Arabidopsis, the effect extends no more than 4 nucleotides on both sides. |
| WOS研究方向 | Life Sciences & Biomedicine - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000240411800012 |
| 出版者 | SCIENCE PRESS |
| 源URL | [http://ir.amss.ac.cn/handle/2S8OKBNM/3881]  |
| 专题 | 中国科学院数学与系统科学研究院 |
| 通讯作者 | Yu Jun |
| 作者单位 | 1.Chinese Acad Sci, Beijing Inst Genom, Beijing 100030, Peoples R China 2.Chinese Acad Sci, Acad Math & Syst Sci, Beijing 100080, Peoples R China 3.Grad Univ, Chinese Acad Sci, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao Hui,Li Qizhai,Li Jun,et al. The study of neighboring nucleotide composition and transition/transversion bias[J]. SCIENCE IN CHINA SERIES C-LIFE SCIENCES,2006,49(4):395-402. |
| APA | Zhao Hui,Li Qizhai,Li Jun,Zeng Changqing,Hu Songnian,&Yu Jun.(2006).The study of neighboring nucleotide composition and transition/transversion bias.SCIENCE IN CHINA SERIES C-LIFE SCIENCES,49(4),395-402. |
| MLA | Zhao Hui,et al."The study of neighboring nucleotide composition and transition/transversion bias".SCIENCE IN CHINA SERIES C-LIFE SCIENCES 49.4(2006):395-402. |
入库方式： OAI收割
来源：数学与系统科学研究院
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