Discrimination of outer membrane proteins by a new measure of information discrepancy
文献类型：期刊论文
| 作者 | Wu, Zikai; Feng, Enmin; Wang, Yong ; Chen, Luonan
|
| 刊名 | PROTEIN AND PEPTIDE LETTERS
 |
| 出版日期 | 2007 |
| 卷号 | 14期号:1页码:37-44 |
| 关键词 | outer membrane protein subsequence distribution FDOD measure |
| ISSN号 | 0929-8665 |
| 英文摘要 | Discriminating outer membrane proteins for globular proteins (GPs) and other types of membrane proteins from genomic sequences is an important and hot topic. In this paper, a measure based on information discrepancy is proposed and applied to the discrimination of outer membrane proteins. It differs from previous methods which are based on amino acid composition. Our approach focuses on the comparison of subsequence distributions and takes into account the effect of residue order in protein primary structures. As a result, the new approach outperforms all previous methods on the same benchmark datasets. In particular, we show that the proposed approach has correctly identified the outer membrane proteins at an accuracy of 99% for the training set of 337 proteins and has correctly excluded the GPs at an accuracy of 86% in a non-redundant dataset of 668 proteins. Furthermore, this method is able to correctly exclude alpha-helical membrane proteins at an accuracy of 100%. |
| WOS研究方向 | Biochemistry & Molecular Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000245376700007 |
| 出版者 | BENTHAM SCIENCE PUBL LTD |
| 源URL | [http://ir.amss.ac.cn/handle/2S8OKBNM/4100]  |
| 专题 | 应用数学研究所 |
| 通讯作者 | Wu, Zikai |
| 作者单位 | 1.Dalian Univ Technol, Dept Appl Math, Dalian 116024, Peoples R China 2.Chinese Acad Sci, Acad Math & Syst Sci, Inst Appl Math, Beijing 100080, Peoples R China 3.Osaka Sangyo Univ, Dept Elect Informat & Commun, Osaka 5748530, Japan 4.Shanghai Univ, Inst Syst Biol, Shanghai 200444, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Zikai,Feng, Enmin,Wang, Yong,et al. Discrimination of outer membrane proteins by a new measure of information discrepancy[J]. PROTEIN AND PEPTIDE LETTERS,2007,14(1):37-44. |
| APA | Wu, Zikai,Feng, Enmin,Wang, Yong,&Chen, Luonan.(2007).Discrimination of outer membrane proteins by a new measure of information discrepancy.PROTEIN AND PEPTIDE LETTERS,14(1),37-44. |
| MLA | Wu, Zikai,et al."Discrimination of outer membrane proteins by a new measure of information discrepancy".PROTEIN AND PEPTIDE LETTERS 14.1(2007):37-44. |
入库方式： OAI收割
来源：数学与系统科学研究院
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