Discovering functions and revealing mechanisms at molecular level from biological networks
文献类型：期刊论文
| 作者 | Zhang, Shihua ; Jin, Guangxu; Zhang, Xiang-Sun; Chen, Luonan
|
| 刊名 | PROTEOMICS
 |
| 出版日期 | 2007-08-01 |
| 卷号 | 7期号:16页码:2856-2869 |
| 关键词 | biological network network analysis network comparison network integration protein interaction network |
| ISSN号 | 1615-9853 |
| DOI | 10.1002/pmic.200700095 |
| 英文摘要 | With the increasingly accumulated data from high-throughput technologies, study on biomolecular networks has become one of key focuses in systems biology and bioinformatics. In particular, various types of molecular networks (e.g., protein-protein interaction (PPI) network; gene regulatory network (GRN); metabolic network (MN); gene coexpression network (GCEN)). have been extensively investigated, and those studies demonstrate great potentials to discover basic functions and to reveal essential mechanisms for various biological phenomena, by understanding biological systems not at individual component level but at a system-wide level. Recent studies on networks have created very prolific researches on many aspects of living organisms. In this paper, we aim to review the recent developments on topics related to molecular networks in a comprehensive manner, with the special emphasis on the computational aspect. The contents of the survey cover global topological properties and local structural characteristics, network motifs, network comparison and query, detection of functional modules and network motifs, function prediction from network analysis, inferring molecular networks from biological data as well as representative databases and software tools. |
| WOS研究方向 | Biochemistry & Molecular Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000249295500014 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://ir.amss.ac.cn/handle/2S8OKBNM/4309]  |
| 专题 | 应用数学研究所 |
| 通讯作者 | Zhang, Xiang-Sun |
| 作者单位 | 1.Chinese Acad Sci, Acad Math & Syst Sci, Beijing 100080, Peoples R China 2.Shanghai Univ, Inst Syst Biol, Shanghai, Peoples R China 3.Osaka Sangyo Univ, Osaka, Japan 4.JST, ERATO, Aihara Complex Modelling Project, Tokyo, Japan 5.Univ Tokyo, Inst Ind Sci, Tokyo, Japan |
| 推荐引用方式 GB/T 7714 | Zhang, Shihua,Jin, Guangxu,Zhang, Xiang-Sun,et al. Discovering functions and revealing mechanisms at molecular level from biological networks[J]. PROTEOMICS,2007,7(16):2856-2869. |
| APA | Zhang, Shihua,Jin, Guangxu,Zhang, Xiang-Sun,&Chen, Luonan.(2007).Discovering functions and revealing mechanisms at molecular level from biological networks.PROTEOMICS,7(16),2856-2869. |
| MLA | Zhang, Shihua,et al."Discovering functions and revealing mechanisms at molecular level from biological networks".PROTEOMICS 7.16(2007):2856-2869. |
入库方式： OAI收割
来源：数学与系统科学研究院
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