Analysis of relation between virologic responses and immunologic responses, patient's factors in AIDS clinical trials using a semiparametric mixed-effects model
文献类型：期刊论文
| 作者 | Liang, Hua; Zou, Guohua |
| 刊名 | BIOMETRICAL JOURNAL
 |
| 出版日期 | 2007-06-01 |
| 卷号 | 49期号:3页码:406-415 |
| 关键词 | AIDS clinical trial HIV dynamics longitudinal data partially linear models regression splines |
| ISSN号 | 0323-3847 |
| DOI | 10.1002/bimj.200610294 |
| 英文摘要 | In this article we propose to use a semiparametric mixed-effects model based on an exploratory analysis of clinical trial data for a study of the relation between virologic responses and immunologic markers such as CD4+ and CD8 counts, and host-specific factors in AIDS clinical trials. The regression spline technique, used for inference for parameters in the model, reduces the unknown nonparametric components to parametric functions. It is simple and straightforward to implement the procedures using readily available software, and parameter inference can be developed from standard parametric models. We apply the model and the proposed method to an AIDS clinical study. Our findings indicate that viral load level is positively related to baseline viral load level, negatively related to CD4+ cell counts, but unrelated to CD8 cell counts and patient's age neither. |
| WOS研究方向 | Mathematical & Computational Biology ; Mathematics |
| 语种 | 英语 |
| WOS记录号 | WOS:000247715800007 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://ir.amss.ac.cn/handle/2S8OKBNM/4721]  |
| 专题 | 中国科学院数学与系统科学研究院 |
| 通讯作者 | Liang, Hua |
| 作者单位 | 1.Univ Rochester, Med Ctr, Dept Biostat & Computat Biol, Rochester, NY 14642 USA 2.Chinese Acad Sci, Acad Math & Syst Sci, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liang, Hua,Zou, Guohua. Analysis of relation between virologic responses and immunologic responses, patient's factors in AIDS clinical trials using a semiparametric mixed-effects model[J]. BIOMETRICAL JOURNAL,2007,49(3):406-415. |
| APA | Liang, Hua,&Zou, Guohua.(2007).Analysis of relation between virologic responses and immunologic responses, patient's factors in AIDS clinical trials using a semiparametric mixed-effects model.BIOMETRICAL JOURNAL,49(3),406-415. |
| MLA | Liang, Hua,et al."Analysis of relation between virologic responses and immunologic responses, patient's factors in AIDS clinical trials using a semiparametric mixed-effects model".BIOMETRICAL JOURNAL 49.3(2007):406-415. |
入库方式： OAI收割
来源：数学与系统科学研究院
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