Genetic Background Comparison Using Distance-Based Regression, with Applications in Population Stratification Evaluation and Adjustment
文献类型：期刊论文
| 作者 | Li, Qizhai1,2 ; Wacholder, Sholom1; Hunter, David J.1,3; Hoover, Robert N.1; Chanock, Stephen1; Thomas, Gilles1; Yu, Kai1
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| 刊名 | GENETIC EPIDEMIOLOGY
 |
| 出版日期 | 2009-07-01 |
| 卷号 | 33期号:5页码:432-441 |
| 关键词 | population stratification pseudo F statistic distance-based regression |
| ISSN号 | 0741-0395 |
| DOI | 10.1002/gepi.20396 |
| 英文摘要 | Population stratification (PS) can lead to an inflated rate of false-positive findings in genome-wide association studies (GWAS). The commonly used approach of adjustment for a fixed number of principal components (PCs) could have a deleterious impact on power when selected PCs are equally distributed in cases and controls, or the adjustment of certain covariates, such as self-identified ethnicity or recruitment center, already included in the association analyses, correctly maps to major axes of genetic heterogeneity. We propose a computationally efficient procedure, PC-Finder, to identify a minimal set of PCs while permitting an effective correction for PS. A general pseudo F statistic, derived from a non-parametric multivariate regression model, can be used to assess whether PS exists or has been adequately corrected by a set of selected PCs. Empirical data from two GWAS conducted as part of the Cancer Genetic Markers of Susceptibility (CGEMS) project demonstrate the application of the procedure. Furthermore, simulation studies show the power advantage of the proposed procedure in GWAS over currently used PS correction strategies, particularly when the PCs with substantial genetic variation are distributed similarly in cases and controls and therefore do not induce PS. Genet. Epidemiol. 33:432-441, 2009. Published 2009 Wiley-Liss, Inc. |
| WOS研究方向 | Genetics & Heredity ; Public, Environmental & Occupational Health |
| 语种 | 英语 |
| WOS记录号 | WOS:000267605700007 |
| 出版者 | WILEY-LISS |
| 源URL | [http://ir.amss.ac.cn/handle/2S8OKBNM/7227]  |
| 专题 | 系统科学研究所 |
| 通讯作者 | Yu, Kai |
| 作者单位 | 1.NCI, Biostat Branch, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA 2.Chinese Acad Sci, Acad Math & Syst Sci, Beijing, Peoples R China 3.Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Program Mol & Genet Epidemiol, Boston, MA 02115 USA |
| 推荐引用方式 GB/T 7714 | Li, Qizhai,Wacholder, Sholom,Hunter, David J.,et al. Genetic Background Comparison Using Distance-Based Regression, with Applications in Population Stratification Evaluation and Adjustment[J]. GENETIC EPIDEMIOLOGY,2009,33(5):432-441. |
| APA | Li, Qizhai.,Wacholder, Sholom.,Hunter, David J..,Hoover, Robert N..,Chanock, Stephen.,...&Yu, Kai.(2009).Genetic Background Comparison Using Distance-Based Regression, with Applications in Population Stratification Evaluation and Adjustment.GENETIC EPIDEMIOLOGY,33(5),432-441. |
| MLA | Li, Qizhai,et al."Genetic Background Comparison Using Distance-Based Regression, with Applications in Population Stratification Evaluation and Adjustment".GENETIC EPIDEMIOLOGY 33.5(2009):432-441. |
入库方式： OAI收割
来源：数学与系统科学研究院
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