中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 数学与系统科学研究院
  3. 中国科学院数学与系统科学研究院
  4. 应用数学研究所
Reverse engineering large-scale genetic networks: synthetic versus real data

文献类型：期刊论文

作者Zhang, Luwen1,2; Xiao, Mei1,2; Wang, Yong3; Zhang, Wu1
刊名JOURNAL OF GENETICS
出版日期2010-04-01
卷号89期号:1页码:73-80
关键词gene regulatory network single gene perturbation linear model stepwise simulated network
ISSN号0022-1333
英文摘要Development of microarray technology has resulted in an exponential rise in gene expression data. Linear computational methods are of great assistance in identifying molecular interactions, and elucidating the functional properties of gene networks. It overcomes the weaknesses of in vivo experiments including high cost, large noise, and unrepeatable process. In this paper, we propose an easily applied system, Stepwise Network Inference (SWNI), which integrates deterministic linear model with statistical analysis, and has been tested effectively on both simulated experiments and real gene expression data sets. The study illustrates that connections of gene networks can be significantly detected via SWNI with high confidence, when single gene perturbation experiments are performed complying with the algorithm requirements. In particular, our algorithm shows efficiency and outperforms the existing ones presented in this paper when dealing with large-scale sparse networks without any prior knowledge.
资助项目Shanghai Leading Academic Discipline Project[J50103]
WOS研究方向Genetics & Heredity
语种英语
WOS记录号WOS:000277769500009
出版者INDIAN ACAD SCIENCES
源URL[http://ir.amss.ac.cn/handle/2S8OKBNM/10953]  
专题应用数学研究所
通讯作者Zhang, Wu
作者单位1.Shanghai Univ, Sch Comp Engn & Sci, Shanghai 200072, Peoples R China
2.Shanghai Univ, Inst Syst Biol, Shanghai 200072, Peoples R China
3.Chinese Acad Sci, Acad Math & Syst Sci, Beijing 100864, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Luwen,Xiao, Mei,Wang, Yong,et al. Reverse engineering large-scale genetic networks: synthetic versus real data[J]. JOURNAL OF GENETICS,2010,89(1):73-80.
APA Zhang, Luwen,Xiao, Mei,Wang, Yong,&Zhang, Wu.(2010).Reverse engineering large-scale genetic networks: synthetic versus real data.JOURNAL OF GENETICS,89(1),73-80.
MLA Zhang, Luwen,et al."Reverse engineering large-scale genetic networks: synthetic versus real data".JOURNAL OF GENETICS 89.1(2010):73-80.

入库方式： OAI收割

来源：数学与系统科学研究院

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。