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Androgen Receptor CAG Repeat Length and Risk of Biliary Tract Cancer and Stones

文献类型：期刊论文

作者Meyer, Tamra E.1; O'Brien, Thomas G.2; Andreotti, Gabriella1; Yu, Kai1; Li, Qizhai1,3; Gao, Yu-Tang5; Rashid, Asif4; Shen, Ming-Chang6; Wang, Bing-Sheng7; Han, Tian-Quan8
刊名CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
出版日期2010-03-01
卷号19期号:3页码:787-793
ISSN号1055-9965
DOI10.1158/1055-9965.EPI-09-0973
英文摘要Biliary tract cancers, encompassing cancers of the gallbladder, extrahepatic bile ducts, and ampulla of Vater, are rare but highly fatal. Gallstones represent the major risk factor for biliary tract cancer, and share with gallbladder cancer a female predominance and an association with reproductive factors and obesity. Although estrogens have been implicated in earlier studies of gallbladder cancer, there are no data on the role of androgens. Because intracellular androgen activity is mediated through the androgen receptor (AR), we examined associations between AR CAG repeat length [(CAG)(n)] and the risk of biliary tract cancers and stones in a population-based study of 331 incident cancer cases, 837 gallstone cases, and 750 controls from Shanghai, China, where the incidence rates for biliary tract cancer are rising sharply. Men with (CAG)(n) >24 had a significant 2-fold risk of gallbladder cancer [odds ratio (OR), 2.00; 95% confidence interval (CI), 1.07-3.73], relative to those with (CAG)(n) <= 22. In contrast, women with (CAG)(n) >24 had reduced gallbladder cancer isk (OR, 0.69; 95% CI, 0.43-1.09) relative to those with (CAG)(n) <= 22; P interaction sex = 0.01, which was most pronounced for women ages 68 to 74 (OR, 0.48; 95% CI, 0.25-0.93; P interaction age = 0.02). No associations were found for bile duct cancer or gallstones. Reasons for the heterogeneity of genetic effects by gender and age are unclear but may reflect an interplay between AR and the levels of androgen as well as estrogen in men and older women. Further studies are needed to confirm these findings and clarify the mechanisms involved. Cancer Epidemiol Biomarkers Prev; 19(3); 787-93. (C) 2010 AACR.
资助项目NIH ; National Cancer Institute, NIH[N01-CO-12400]
WOS研究方向Oncology ; Public, Environmental & Occupational Health
语种英语
WOS记录号WOS:000278475300019
出版者AMER ASSOC CANCER RESEARCH
源URL[http://ir.amss.ac.cn/handle/2S8OKBNM/10980]  
专题系统科学研究所
通讯作者Meyer, Tamra E.
作者单位1.NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA
2.Lankenau Inst Med Res, Wynnewood, PA USA
3.Chinese Acad Sci, Acad Math & Syst Sci, Key Lab Syst & Control, Beijing, Peoples R China
4.Univ Texas MD Anderson Canc Ctr, Dept Pathol, Houston, TX 77030 USA
5.Shanghai Canc Inst, Shanghai 200433, Peoples R China
6.Shanghai Tumor Hosp, Shanghai, Peoples R China
7.Fudan Univ, Zhongshan Hosp, Shanghai 200433, Peoples R China
8.Shanghai Med Univ 2, Ruijin Hosp, Dept Surg, Shanghai, Peoples R China
9.Second Mil Med Univ, Inst Oriental Hepatobiliary Surg, Shanghai, Peoples R China
10.WESTAT Corp, Rockville, MD 20850 USA
推荐引用方式
GB/T 7714		 Meyer, Tamra E.,O'Brien, Thomas G.,Andreotti, Gabriella,et al. Androgen Receptor CAG Repeat Length and Risk of Biliary Tract Cancer and Stones[J]. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION,2010,19(3):787-793.
APA Meyer, Tamra E..,O'Brien, Thomas G..,Andreotti, Gabriella.,Yu, Kai.,Li, Qizhai.,...&Hsing, Ann W..(2010).Androgen Receptor CAG Repeat Length and Risk of Biliary Tract Cancer and Stones.CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION,19(3),787-793.
MLA Meyer, Tamra E.,et al."Androgen Receptor CAG Repeat Length and Risk of Biliary Tract Cancer and Stones".CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION 19.3(2010):787-793.

入库方式： OAI收割

来源：数学与系统科学研究院

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