Bayes factors in the presence of population stratification
文献类型：期刊论文
| 作者 | Wang, Linglu2; Li, Qizhai3 ; Li, Zhaohai2; Zheng, Gang1
|
| 刊名 | STATISTICS & PROBABILITY LETTERS
 |
| 出版日期 | 2011-07-01 |
| 卷号 | 81期号:7页码:836-841 |
| 关键词 | Approximate Bayes factor Clustering Genome-wide association studies Odds ratio Population stratification |
| ISSN号 | 0167-7152 |
| DOI | 10.1016/j.spl.2011.02.020 |
| 英文摘要 | Hidden population stratification (PS) is a main concern in the analysis of case-control genetic association studies. All methods to correct for hidden PS have been focused on classical hypothesis testing, and cannot be directly applied to Bayesian analysis. In this paper, to study the impact and the correction of hidden PS on Bayes factor (BF), we use a simple approximation of BF in terms of the maximum likelihood estimates of the odds ratio (OR) and its asymptotic variance. One advantage is that the commonly used principal components analysis method with a large panel of null markers scanned from existing genome-wide association studies can be directly employed to correct for hidden PS in estimating the OR and its asymptotic variance, through which a correction to BF for hidden PS can be achieved. Using simulations, we examine the impact of ignoring hidden PS on BF and show that the proposed method yields an appropriate correction in Bayesian analysis. Published by Elsevier B.V. |
| 资助项目 | National Young Science Foundation of China[10901155] |
| WOS研究方向 | Mathematics |
| 语种 | 英语 |
| WOS记录号 | WOS:000291175200017 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://ir.amss.ac.cn/handle/2S8OKBNM/11259]  |
| 专题 | 系统科学研究所 |
| 通讯作者 | Zheng, Gang |
| 作者单位 | 1.NHLBI, Off Biostat Res, Bethesda, MD 20892 USA 2.George Washington Univ, Dept Stat, Washington, DC 20052 USA 3.Chinese Acad Sci, Acad Math & Syst Sci, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Linglu,Li, Qizhai,Li, Zhaohai,et al. Bayes factors in the presence of population stratification[J]. STATISTICS & PROBABILITY LETTERS,2011,81(7):836-841. |
| APA | Wang, Linglu,Li, Qizhai,Li, Zhaohai,&Zheng, Gang.(2011).Bayes factors in the presence of population stratification.STATISTICS & PROBABILITY LETTERS,81(7),836-841. |
| MLA | Wang, Linglu,et al."Bayes factors in the presence of population stratification".STATISTICS & PROBABILITY LETTERS 81.7(2011):836-841. |
入库方式： OAI收割
来源：数学与系统科学研究院
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