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Adjustment of basal insulin infusion rate in T1DM by hybrid PSO

文献类型：期刊论文

作者Lou, Zhijiang1; Liu, Bo2; Xie, Hongzhi1; Wang, Youqing1
刊名SOFT COMPUTING
出版日期2015-07-01
卷号19期号:7页码:1921-1937
关键词Particle swarm optimization (PSO) Glycemic control Basal insulin infusion rate optimization Type 1 diabetes mellitus
ISSN号1432-7643
DOI10.1007/s00500-014-1378-6
英文摘要Basal insulin infusion rate which should be adjusted to increase or decrease insulin delivery with the varying blood sugar level plays a key role in type 1 diabetes mellitus (T1DM) patients for maintaining the blood glucose level approximately steady within reference range in order to avoid the complications developed from diabetes. This paper proposes an effective hybrid particle swarm optimization (HPSO) algorithm for solving the basal insulin infusion rate problem. In HPSO, bad experience lesson learning scheme and local search based on chaotic dynamics are proposed to make a good balance between global exploration and local exploitation. Simulation results based on a set of well-known optimization benchmark instances and the basal insulin infusion rate adjustment problem for T1DM demonstrate the effectiveness of the proposed HPSO. In silico tests on standard virtual subject via HPSO show that under nominal condition the blood glucose concentrations could be kept within a range of 80-150 mg/dL within less than 5 days; meanwhile, in case of random variations in meal timings within 60 min or meal amounts within 75 % deviation from the nominal values, the blood glucose concentrations could be kept within the safe regions.
资助项目National Natural Science Foundation of China[61374099] ; National Natural Science Foundation of China[71101139] ; Beijing Nova Program[2011025] ; EFSD/CDS/Lilly grant ; Fok Ying-Tong Education Foundation[131060]
WOS研究方向Computer Science
语种英语
WOS记录号WOS:000355934500012
出版者SPRINGER
源URL[http://ir.amss.ac.cn/handle/2S8OKBNM/20018]  
专题系统科学研究所
通讯作者Wang, Youqing
作者单位1.Beijing Univ Chem Technol, Coll Informat Sci & Technol, Beijing 100029, Peoples R China
2.Chinese Acad Sci, Acad Math & Syst Sci, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Lou, Zhijiang,Liu, Bo,Xie, Hongzhi,et al. Adjustment of basal insulin infusion rate in T1DM by hybrid PSO[J]. SOFT COMPUTING,2015,19(7):1921-1937.
APA Lou, Zhijiang,Liu, Bo,Xie, Hongzhi,&Wang, Youqing.(2015).Adjustment of basal insulin infusion rate in T1DM by hybrid PSO.SOFT COMPUTING,19(7),1921-1937.
MLA Lou, Zhijiang,et al."Adjustment of basal insulin infusion rate in T1DM by hybrid PSO".SOFT COMPUTING 19.7(2015):1921-1937.

入库方式： OAI收割

来源：数学与系统科学研究院

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