Revealing Potential Biomarkers of Functional Dyspepsia by Combining H-1 NMR Metabonomics Techniques and an Integrative Multi-objective Optimization Method
文献类型：期刊论文
| 作者 | Wu, Qiaofeng1; Zou, Meng2; Yang, Mingxiao1; Zhou, Siyuan1; Yan, Xianzhong3; Sun, Bo3; Wang, Yong2 ; Chang, Shyang4; Tang, Yong1; Liang, Fanrong1
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| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2016-01-08 |
| 卷号 | 6页码:10 |
| ISSN号 | 2045-2322 |
| DOI | 10.1038/srep18852 |
| 英文摘要 | Metabonomics methods have gradually become important auxiliary tools for screening disease biomarkers. However, recognition of metabolites or potential biomarkers closely related to either particular clinical symptoms or prognosis has been difficult. The current study aims to identify potential biomarkers of functional dyspepsia (FD) by a new strategy that combined hydrogen nuclear magnetic resonance (H-1 NMR)-based metabonomics techniques and an integrative multi-objective optimization (LPIMO) method. First, clinical symptoms of FD were evaluated using the Nepean Dyspepsia Index (NDI), and plasma metabolic profiles were measured by H-1 NMR. Correlations between the key metabolites and the NDI scores were calculated. Then, LPIMO was developed to identify a multi-biomarker panel by maximizing diagnostic ability and correlation with the NDI score. Finally, a KEGG database search elicited the metabolic pathways in which the potential biomarkers are involved. The results showed that glutamine, alanine, proline, HDL, beta-glucose, alpha-glucose and LDL/VLDL levels were significantly altered in FD patients. Among them, phosphatidycholine (PtdCho) and leucine/isoleucine (Leu/Ile) were positively and negatively correlated with the NDI Symptom Index (NDSI) respectively. Our procedure not only significantly improved the credibility of the biomarkers, but also demonstrated the potential of further explorations and applications to diagnosis and treatment of complex disease. |
| 资助项目 | National Natural Science Foundation of China[81373737] ; National Natural Science Foundation of China[11422108] ; National Basic Research Program of China[2012CB518501] ; Fok Ying-Tong Education Foundation, China[141041] ; Department of Science and Technology Fund of Sichuan Province[2015JQO058] |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000368677000001 |
| 出版者 | NATURE PUBLISHING GROUP |
| 源URL | [http://ir.amss.ac.cn/handle/2S8OKBNM/21814]  |
| 专题 | 应用数学研究所 |
| 通讯作者 | Liang, Fanrong; Yu, Shuguang |
| 作者单位 | 1.Chengdu Univ Tradit Chinese Med, Acupuncture & Tuina Coll, Chengdu 610075, Sichuan, Peoples R China 2.Chinese Acad Sci, Acad Math & Syst Sci, Natl Ctr Math & Interdisciplinary Sci, Beijing 100080, Peoples R China 3.Natl Ctr Biomed Anal, Beijing 100850, Peoples R China 4.Natl Tsing Hua Univ, Dept Elect Engn, Hsinchu 300, Taiwan |
| 推荐引用方式 GB/T 7714 | Wu, Qiaofeng,Zou, Meng,Yang, Mingxiao,et al. Revealing Potential Biomarkers of Functional Dyspepsia by Combining H-1 NMR Metabonomics Techniques and an Integrative Multi-objective Optimization Method[J]. SCIENTIFIC REPORTS,2016,6:10. |
| APA | Wu, Qiaofeng.,Zou, Meng.,Yang, Mingxiao.,Zhou, Siyuan.,Yan, Xianzhong.,...&Yu, Shuguang.(2016).Revealing Potential Biomarkers of Functional Dyspepsia by Combining H-1 NMR Metabonomics Techniques and an Integrative Multi-objective Optimization Method.SCIENTIFIC REPORTS,6,10. |
| MLA | Wu, Qiaofeng,et al."Revealing Potential Biomarkers of Functional Dyspepsia by Combining H-1 NMR Metabonomics Techniques and an Integrative Multi-objective Optimization Method".SCIENTIFIC REPORTS 6(2016):10. |
入库方式： OAI收割
来源：数学与系统科学研究院
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