Detection of Interactions between Proteins through Rotation Forest and Local Phase Quantization Descriptors
文献类型：期刊论文
| 作者 | Wong, Leon1; You, Zhu-Hong2; Ming, Zhong1; Li, Jianqiang1; Chen, Xing3; Huang, Yu-An1 |
| 刊名 | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
 |
| 出版日期 | 2016 |
| 卷号 | 17期号:1页码:11 |
| 关键词 | protein-protein interaction Rotation Forest Physicochemical Property Response Matrix (PR) Local Phase Quantization |
| ISSN号 | 1422-0067 |
| DOI | 10.3390/ijms17010021 |
| 英文摘要 | Protein-Protein Interactions (PPIs) play a vital role in most cellular processes. Although many efforts have been devoted to detecting protein interactions by high-throughput experiments, these methods are obviously expensive and tedious. Targeting these inevitable disadvantages, this study develops a novel computational method to predict PPIs using information on protein sequences, which is highly efficient and accurate. The improvement mainly comes from the use of the Rotation Forest (RF) classifier and the Local Phase Quantization (LPQ) descriptor from the Physicochemical Property Response (PR) Matrix of protein amino acids. When performed on three PPI datasets including Saccharomyces cerevisiae, Homo sapiens, and Helicobacter pylori, we obtained good results of average accuracies of 93.8%, 97.96%, and 89.47%, which are much better than in previous studies. Extensive validations have also been explored to evaluate the performance of the Rotation Forest ensemble classifier with the state-of-the-art Support Vector Machine classifier. These promising results indicate that the proposed method might play a complementary role for future proteomics research. |
| 资助项目 | National Science Foundation of China[61373086] ; National Science Foundation of China[61401385] ; National Science Foundation of China[11301517] ; Guangdong Natural Science Foundation[2014A030313555] ; Shenzhen Scientific Research and Development Funding Program[JCYJ20140418095735569] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000374583800021 |
| 出版者 | MDPI AG |
| 源URL | [http://ir.amss.ac.cn/handle/2S8OKBNM/22810]  |
| 专题 | 中国科学院数学与系统科学研究院 |
| 通讯作者 | You, Zhu-Hong |
| 作者单位 | 1.Shenzhen Univ, Coll Comp Sci & Software Engn, Shenzhen 518060, Peoples R China 2.China Univ Min & Technol, Sch Comp Sci & Technol, Xuzhou 221116, Peoples R China 3.Chinese Acad Sci, Acad Math & Syst Sci, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wong, Leon,You, Zhu-Hong,Ming, Zhong,et al. Detection of Interactions between Proteins through Rotation Forest and Local Phase Quantization Descriptors[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2016,17(1):11. |
| APA | Wong, Leon,You, Zhu-Hong,Ming, Zhong,Li, Jianqiang,Chen, Xing,&Huang, Yu-An.(2016).Detection of Interactions between Proteins through Rotation Forest and Local Phase Quantization Descriptors.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,17(1),11. |
| MLA | Wong, Leon,et al."Detection of Interactions between Proteins through Rotation Forest and Local Phase Quantization Descriptors".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 17.1(2016):11. |
入库方式： OAI收割
来源：数学与系统科学研究院
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