Genetic risks and genetic model specification
文献类型：期刊论文
| 作者 | Zheng, Gang1; Zhang, Wei2; Xu, Jinfeng3; Yuan, Ao4; Li, Qizhai2 ; Gastwirth, Joseph L.5
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| 刊名 | JOURNAL OF THEORETICAL BIOLOGY
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| 出版日期 | 2016-08-21 |
| 卷号 | 403页码:68-74 |
| 关键词 | Case-control design Genetic model Genetic risk Hardy-Weinberg equilibrium |
| ISSN号 | 0022-5193 |
| DOI | 10.1016/j.jtbi.2016.05.016 |
| 英文摘要 | Genetic risks and genetic models are often used in design and analysis of genetic epidemiology studies. A genetic model is defined in terms of two genetic risk measures: genotype relative risk and odds ratio. The impacts of choosing a risk measure on the resulting genetic models are studied in the power to detect association and deviation from Hardy Weinberg equilibrium in cases using genetic relative risk. Extensive simulations demonstrate that the power of a study to detect associations using odds ratio is lower than that using relative risk with the same value when other parameters are fixed. When the Hardy Weinberg equilibrium holds in the general population, the genetic model can be inferred by the deviation from Hardy Weinberg equilibrium in only cases. Furthermore, it is more efficient than that based on the deviation from Hardy-Weinberg equilibrium in all cases and controls. (C) 2016 Elsevier Ltd. All rights reserved. |
| 资助项目 | National Science Foundation of China[11371353] ; National Science Foundation of China[61134013] ; Chinese Academy of Sciences[XDB13040600] |
| WOS研究方向 | Life Sciences & Biomedicine - Other Topics ; Mathematical & Computational Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000378987100008 |
| 出版者 | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD |
| 源URL | [http://ir.amss.ac.cn/handle/2S8OKBNM/23074]  |
| 专题 | 系统科学研究所 |
| 通讯作者 | Yuan, Ao |
| 作者单位 | 1.NHLBI, Bldg 10, Bethesda, MD 20892 USA 2.Chinese Acad Sci, Acad Math & Syst Sci, Key Lab Syst & Control, Beijing, Peoples R China 3.Univ Hong Kong, Hong Kong, Hong Kong, Peoples R China 4.Georgetown Univ, Washington, DC 20057 USA 5.George Washington Univ, Washington, DC USA |
| 推荐引用方式 GB/T 7714 | Zheng, Gang,Zhang, Wei,Xu, Jinfeng,et al. Genetic risks and genetic model specification[J]. JOURNAL OF THEORETICAL BIOLOGY,2016,403:68-74. |
| APA | Zheng, Gang,Zhang, Wei,Xu, Jinfeng,Yuan, Ao,Li, Qizhai,&Gastwirth, Joseph L..(2016).Genetic risks and genetic model specification.JOURNAL OF THEORETICAL BIOLOGY,403,68-74. |
| MLA | Zheng, Gang,et al."Genetic risks and genetic model specification".JOURNAL OF THEORETICAL BIOLOGY 403(2016):68-74. |
入库方式： OAI收割
来源：数学与系统科学研究院
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