Models of global gene expression define major domains of cell type and tissue identity
文献类型：期刊论文
| 作者 | Hutchins, Andrew P.1,2,3; Yang, Zhongzhou2,3; Li, Yuhao1; He, Fangfang1; Fu, Xiuling1; Wang, Xiaoshan2,3; Li, Dongwei2,3; Liu, Kairong4,5; He, Jiangping2,3; Wang, Yong4
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| 刊名 | NUCLEIC ACIDS RESEARCH
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| 出版日期 | 2017-03-17 |
| 卷号 | 45期号:5页码:2354-2367 |
| ISSN号 | 0305-1048 |
| DOI | 10.1093/nar/gkx054 |
| 英文摘要 | The current classification of cells in an organism is largely based on their anatomic and developmental origin. Cells types and tissues are traditionally classified into those that arise from the three embryonic germ layers, the ectoderm, mesoderm and endoderm, but this model does not take into account the organization of cell type-specific patterns of gene expression. Here, we present computational models for cell type and tissue specification derived from a collection of 921 RNA-sequencing samples from 272 distinct mouse cell types or tissues. In an unbiased fashion, this analysis accurately predicts the three known germ layers. Unexpectedly, this analysis also suggests that in total there are eight major domains of cell type-specification, corresponding to the neurectoderm, neural crest, surface ectoderm, endoderm, mesoderm, blood mesoderm, germ cells and the embryonic domain. Further, we identify putative genes responsible for specifying the domain and the cell type. This model has implications for understanding trans-lineage differentiation for stem cells, developmental cell biology and regenerative medicine. |
| 资助项目 | National Natural Science Foundation of China[31471242] ; National Natural Science Foundation of China[31550110206] ; National Natural Science Foundation of China[11422108] ; NSFC grants ; core Shenzhen funding |
| WOS研究方向 | Biochemistry & Molecular Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000397286600020 |
| 出版者 | OXFORD UNIV PRESS |
| 源URL | [http://ir.amss.ac.cn/handle/2S8OKBNM/24914]  |
| 专题 | 应用数学研究所 |
| 通讯作者 | Hutchins, Andrew P.; Pei, Duanqing |
| 作者单位 | 1.Southern Univ Sci & Technol China, Dept Biol, Shenzhen 518055, Guangdong, Peoples R China 2.Chinese Acad Sci, Key Lab Regenerat Biol, Guangzhou 510530, Guangdong, Peoples R China 3.Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Guangdong Prov Key Lab Stem Cells & Regenerat Med, Guangzhou 510530, Guangdong, Peoples R China 4.Chinese Acad Sci, Acad Math & Syst Sci, Natl Ctr Math & Interdisciplinary Sci, Beijing 100080, Peoples R China 5.Beihang Univ, Beijing 100191, Peoples R China 6.Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Lab RNA Chromatin & Human Dis, Guangzhou 510530, Guangdong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hutchins, Andrew P.,Yang, Zhongzhou,Li, Yuhao,et al. Models of global gene expression define major domains of cell type and tissue identity[J]. NUCLEIC ACIDS RESEARCH,2017,45(5):2354-2367. |
| APA | Hutchins, Andrew P..,Yang, Zhongzhou.,Li, Yuhao.,He, Fangfang.,Fu, Xiuling.,...&Pei, Duanqing.(2017).Models of global gene expression define major domains of cell type and tissue identity.NUCLEIC ACIDS RESEARCH,45(5),2354-2367. |
| MLA | Hutchins, Andrew P.,et al."Models of global gene expression define major domains of cell type and tissue identity".NUCLEIC ACIDS RESEARCH 45.5(2017):2354-2367. |
入库方式： OAI收割
来源：数学与系统科学研究院
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